Results 151 to 160 of about 927,717 (352)

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
Soluble GRP78 (sGRP78) is identified as a novel tumor‐derived soluble factor that induces regulatory T cells (Treg). sGRP78 serves as an excellent serological biomarker for predicting the efficacy of neoadjuvant therapy in breast cancer patients. sGRP78 specifically binds to B cells, inducing the expression of IL‐10 and PD‐L1, thereby promoting Treg ...
Zhenghao Wu, Peng Zheng, Yunxiao Xiao, Qianheng Wang, Xin Pan, Xiaoqi Zhou, Yibing Lv, Junyi Xiao, Yong He, Tao Huang, Ping Lei   +10 more
wiley   +1 more source

One-year mortality and re-admission rate by disease etiology in National Heart Failure Registry of India

Nature Communications
Survival outcomes of patients with heart failure (HF) based on their disease etiology are not well described. Here, we provide one-year mortality outcomes of 10850 patients with HF (mean age = 59.9 years, 31% women) in India. Ischemic heart disease (71.9%
Sivadasanpillai Harikrishnan, Ajay Bahl, Ambuj Roy, Animesh Mishra, Jayesh Prajapati, CN Manjunath, Rishi Sethi, Santanu Guha, Santhosh Satheesh, RS Dhaliwal, Meenakshi Sharma, Sanjay Ganapathy, Panniyammakal Jeemon   +12 more
doaj   +1 more source

Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. [PDF]

, 1968
A. G. Shaper, M. S. R. Hutt, Ruth M. Coles   +2 more
openalex   +1 more source

GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity

Advanced Science, EarlyView.
This study leverages NHANES data to analyze 49 routine indicators, identifying the top 10 diagnostic markers for five major diseases and introducing GLM7, a novel indicator. Restricted cubic spline analyses, forest plot evaluations, and XGBoost modeling demonstrate conventional indicators' efficacy and GLM7's value for disease diagnosis/prediction ...
Zhihua Wang, Shuo Chen, Xiaojun Feng, Xi Chen, Paul C Evans, Hans Strijdom, Yu Ding, Jianping Weng, Suowen Xu   +8 more
wiley   +1 more source

Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015

New England Journal of Medicine, 2017
D. Watkins, C. Johnson, Samantha M. Colquhoun, G. Karthikeyan, A. Beaton, G. Bukhman, M. Forouzanfar, C. Longenecker, B. Mayosi, G. Mensah, B. Nascimento, A. Ribeiro, C. Sable, A. Steer, M. Naghavi, A. Mokdad, C. Murray, T. Vos, J. Carapetis, Gregory A. Roth   +19 more
semanticscholar   +1 more source

Rheumatic fever and rheumatic heart disease in children below the age of 5 years in the tropics. [PDF]

, 1965
Z H Abdin, Ayman Eissa
openalex   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

Advanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen   +9 more
wiley   +1 more source

Induction of Myocarditis and Valvuluitis in Lewis Rats by Different Epitopes of Cardiac Myosin and its Implications in Rheumatic Carditis [PDF]

, 2002
Immune responses against cardiac myosin and group A streptococcal M protein have been implicated in the pathogenesis of rheumatic heart disease.
Cunningham, Madeleine W., Factor, Stephen M., Galvin, Jeffrey E., Hemric, Mark E., Konsanke, Stanley D., Quinn, Anthony   +5 more
core  

Rheumatic Fever and Rheumatic Heart Disease among U.S. College Freshmen, 1956-60: Prevalence, Prophylaxis [PDF]

, 1964
Carl J. Marienfeld, Morton Robins, Roy P. Sandidge, Clare Findlan   +3 more
openalex   +1 more source