Results 101 to 110 of about 315,994 (289)

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

Diverse Treatment Goals in Psoriatic Arthritis: Insights From Participants in the PARC Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to examine patient‐reported treatment goals among individuals with psoriatic arthritis. Methods Participants in the Psoriatic Arthritis Research Consortium completed standardized assessments, including patient‐reported outcome (PROs) instruments, between 2017 and 2020.
Astia Allenzara, Kathleen Bush, M. Elaine Husni, Soumya M. Reddy, Jose U. Scher, Ethan Craig, Joelle Koplin, Jessica A. Walsh, Alexis Ogdie   +8 more
wiley   +1 more source

LASSO-Patternsearch algorithm with application to ophthalmology and genomic data [PDF]

arXiv, 2006
The LASSO-Patternsearch algorithm is proposed to efficiently identify patterns of multiple dichotomous risk factors for outcomes of interest in demographic and genomic studies. The patterns considered are those that arise naturally from the log linear expansion of the multivariate Bernoulli density.
arxiv  

Cardiovascular risk assessment and management in rheumatoid arthritis : are guidelines being followed? [PDF]

, 2014
Aim: The aim of the audit was to determine whether the cardiovascular risk assessment and management in rheumatoid arthritis patients at Mater Dei Hospital is in concordance with the recommendations by the European League Against Rheumatism (EULAR ...
Borg, Andrew A., Buhagiar, Malcolm, Magro, Rosalie, Taliana, Nikita   +3 more
core  

Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population [PDF]

, 2013
Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis.
Bidmeshkipour, A., Gharaei, R., Samadian, E., Shirkavand, A., Soleymani-Nejadian, E.   +4 more
core   +2 more sources

Barriers and Facilitators for Implementing Resilience Coaching for Youth With Chronic Musculoskeletal Pain: Pediatric Rheumatologists’ Perspectives

Arthritis Care &Research, EarlyView.
Objective Promoting Resilience in Stress Management (PRISM) is a resilience coaching program designed for adolescents with chronic illness. We aimed to examine the perceived feasibility, acceptability, and appropriateness of PRISM among pediatric rheumatologists treating adolescents with chronic musculoskeletal pain and obtain recommendations for ...
Sabrina Gmuca, Anyun Chatterjee, Mackenzie McGill, Nellie Butler, Katherine S. Kellom, Jami F. Young, Tonya M. Palermo, Pamela F. Weiss, Abby R. Rosenberg, Peter F. Cronholm   +9 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Functional implications of B lymphocytes in the development of rheumatoid arthritis [PDF]

MedUNAB, 2006
B cells play a key role in regulating the immune system by producingantibodies, acting as antigen-presenting cells, providing support toother mononuclear cells, and contributing directly to inflammatorypathways. Accumulating evidence indicates that there
Juan-Manuel Anaya, Luis Miguel Gómez, María-Carolina Páez Leal   +2 more
doaj  

Good Arm Identification via Bandit Feedback [PDF]

arXiv, 2017
We consider a novel stochastic multi-armed bandit problem called {\em good arm identification} (GAI), where a good arm is defined as an arm with expected reward greater than or equal to a given threshold. GAI is a pure-exploration problem that a single agent repeats a process of outputting an arm as soon as it is identified as a good one before ...
arxiv  

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial [PDF]

, 2016
Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA).
Chen, Li-Na, Deng, Xue-Rong, Fang, Yong-Fei, Gu, Fei, Hao, Yan-Jie, He, Jing, Keystone, Edward, Li, Ru, Li, Xing-Fu, Li, Zhan-Guo, Liu, Hua-Xiang, Liu, Xiang-Yuan, Liu, Yi, McInnes, Iain B., Su, Yin, Sun, Ling-Yun, Xue, Yu, Zhang, Zhuo-Li, Zhao, Cheng, Zhao, Jin-Xia, Zhao, Yi, Zhou, Wei, Zhu, Ping, Zou, He-Jian, Zou, Qing-Hua   +24 more
core   +3 more sources