Results 161 to 170 of about 315,994 (289)

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

Anticitrullin antibodies modern markers of rheumatoid arthritis

Терапевтический архив, 2011
Modern diagnosis of rheumatoid arthritis (RA) is based on the ARA criteria with seropositivity detection by the rheumatoid factor (RF). In a clinically evident stage of the disease this factor is highly sensitive and specific (about 90%), but in early RA
Natal'ya Petrovna Shilkina, Mariya Sergeevna Luzinova, Aleksey Alekseevich Vinogradov, N P Shilkina, M S Luzinova, A A Vinogradov   +5 more
doaj  

Clinical Spectrum of Juvenile Idiopathic Arthritis in Children in Tertiary Care Hospital

Pakistan Journal of Medicine and Dentistry
Background: Juvenile idiopathic arthritis (JIA) an autoimmune illness affects infants and teenagers worldwide. The study aimed to find the clinical, laboratory, therapeutic, and demographic characteristics associated with JIA patients in a tertiary care
Mian Saleem Shah, Inam Ullah, Abdul Hameed, Nighat Parveen, Shifa A Khan, Khurram Saleem   +5 more
doaj   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Influence of rheumatoid factor levels and TNF inhibitor structure on secondary nonresponse in rheumatoid arthritis patients

Frontiers in Medicine
BackgroundThe EXXELERATE study revealed poorer clinical outcomes in patients treated with adalimumab (ADL) and baseline rheumatoid factor (RF) above 203 IU/mL.
Chamaida Plasencia-Rodríguez, Chamaida Plasencia-Rodríguez, Ana Martínez-Feito, Ana Martínez-Feito, Marta Novella-Navarro, Marta Novella-Navarro, Rebeca Pérez De Diego, Rebeca Pérez De Diego, Rebeca Pérez De Diego, Gema Bonilla, Gema Bonilla, Johanna Elin Gehin, Alejandro Villalba-Yllán, Laura Nuño, Dora Pascual-Salcedo, Pilar Nozal, Pilar Nozal, Mariana Díaz Almirón, Alejandro Balsa, Alejandro Balsa   +19 more
doaj   +1 more source

B cell reductive therapy with rituximab in the treatment of rheumatoid arthritis. [PDF]

, 2009
The approach to treating autoimmune disorders is currently undergoing a significant change in focus. As therapies are developed that are more precise in targeting the pathogenesis for these diseases, patients experience significantly fewer side effects ...
Sands, Jacob, Tuscano, Joseph M
core   +2 more sources

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Rheumatoid arthritis-associated rheumatoid factors post-COVID-19

Frontiers in Immunology
ObjectiveRheumatoid factors (RFs) are a hallmark of rheumatoid arthritis but also arise in infections, including COVID-19. Moreover, infections, again including COVID-19, are associated with rheumatoid arthritis development, positioning RFs as a ...
Adam H. Titi, Braedon T. Krisko, S. Janna Bashar, Ryan R. Adyniec, Maxwell H. Parker, Nat F. Murren, Courtney B. Myhr, Miriam A. Shelef, Miriam A. Shelef   +8 more
doaj   +1 more source

Rheumatoid factor and rheumatoid arthritis [PDF]

Journal of Clinical Orthopaedics and Trauma, 2019
openaire   +2 more sources

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source