Results 221 to 230 of about 213,613 (314)

Advances in Medical Devices for Augmented Acupuncture Therapy

Advanced Science, EarlyView.
Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai, Chenyi Yu, Xinyi Luo, Ningyu Xu, Jicheng Yu, Xiao Ye, Yuqi Zhang, Zhen Gu   +7 more
wiley   +1 more source

Next-generation rheumatoid factor assay provides improved predictive power for the development of arthritis in patients at risk. [PDF]

RMD Open
Oskam N, Ooijevaar-de Heer P, Kos D, van Boheemen L, van Schaardenburg D, Wolbink G, Rispens T.   +6 more
europepmc   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions. [PDF]

Rheumatol Ther
Oliveira VDRS, Reis APMG, Brenol CV, Pereira IA, Bonfiglioli KR, Pereira LR, Bértolo MB, de Fátima L C Sauma M, Guimarães MFBR, Louzada-Júnior P, Giorgi RDN, Radominski SC, Mota LMH, Albuquerque CP, Castelar-Pinheiro GR.   +14 more
europepmc   +1 more source

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

The Serological Evidence of Positive Rheumatoid Factor in Morphea Patients and Its Relation to Disease Severity. [PDF]

Cureus
Al-Nasrawi AN, Abdulkareem AS, Mohammed Ali MN.   +2 more
europepmc   +1 more source

Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

Advanced Science, EarlyView.
TPP‐SAT, a mitochondria‐targeted natural enzyme‐cascade nanogel, selectively scavenges mitochondrial ROS (e.g., H2O2/·O2⁻) and converts them into therapeutic O2 via enzymatic cascades, alleviating hypoxia and inflammation. It rebalances M1/M2 macrophage polarization, activates the Nrf2 pathway while suppressing NF‐κB, enhances antioxidant defenses, and
Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu   +6 more
wiley   +1 more source

Real-world clinical outcomes and rationale for initiating abatacept as a first-line biologic for patients with anticitrullinated protein antibody- and rheumatoid factor-positive rheumatoid arthritis. [PDF]

J Comp Eff Res
Balanean A, Brown-Bickerstaff C, Klink A, Patel V, Zheng H, N'Dri L, Wittstock K, Feinberg B, Chaballa M, Khaychuk V, Kaufman J, Pathak P, Lam G.   +12 more
europepmc   +1 more source

Strain‐Sensitive Thermochromic Smart Electronic Skin for Joint and Spine Healthcare Applications

Advanced Science, EarlyView.
iStretch, a multifunctional e‐skin integrating durable strain sensing, adaptive heat therapy, and visual feedback, is presented for joint and spine rehabilitation. Featuring a bilayer graphene–liquid metal design, iStretch offers high sensitivity, real‐time responsiveness, and user interactivity, enabling personalized musculoskeletal care through ...
Shicheng Fan, Shuwen Chen, Zheng Qiao, Jiaming Qi, Zixiong Wu, Chwee Teck Lim   +5 more
wiley   +1 more source

The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach. [PDF]

Immunol Res
Heutz JW, Looijen AEM, Kuijpers JHSAM, Schreurs MWJ, van der Helm-van Mil AHM, de Jong PHP.   +5 more
europepmc   +1 more source