Results 41 to 50 of about 4,445,450 (251)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evaluation of VDRL Test in Patients Rheumatoid Arthritis [PDF]
پیاورد سلامت, 2008 Background and Aim: Rheumatoid arthritis is a systemic, chronic and inflammatory disease. It is characterized by the symmetric synovitis of the articules of the extremities.
P Ekhtiyari +3 more
doaj +2 more sources
Wrong Sample Dispensing May Cause False Positive Malaria Test [PDF]
Journal of Clinical and Diagnostic Research, 2015 Both false positive (FP) and false negative are known limitations of any diagnostic test. Malaria parasite (MP) rapid diagnostic tests (RDTs) may give FP results due to interference by substance in blood sample.
Naveen Agnihotri, Ajju Agnihotri
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Constrictive Pericarditis and Rheumatoid Nodules with Severe Aortic Incompetence [PDF]
, 2014 The case of a female patient presenting with constrictive rheumatoid pericarditis and aortic incompetence secondary to valvular rheumatoid nodules is described along with a review of the literature with the aim to highlight this rare cause of aortic ...
Herron, B +9 more
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Treating Rheumatoid Arthritis yesterday and today [PDF]
, 2004 Rheumatoid arthritis is a chronic, systemic inflammatory disorder that mainly affects joints. It is the most common form of inflammatory joint disease, and the second commonest joint disease, osteoarthritis being the commonest.
Mallia, Carmel
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Rheumatoid Factors: Clinical Applications [PDF]
Disease Markers, 2013 Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects.
Francesca Ingegnoli +2 more
openaire +4 more sources
Revista Brasileira de Reumatologia, 2009 INTRODUÇÃO: O fator reumatoide (FR), apesar de suas limitações, ainda é o marcador sorológico mais utilizado para diagnóstico da artrite reumatoide (AR) inicial. Há controvérsias sobre sensibilidade, especificidade, correlação com prognóstico radiológico
Licia Maria Henrique da Mota +3 more
doaj +1 more source