Results 91 to 100 of about 202,977 (306)
Revista Enfermagem UERJ, 2015 As doenças crônicas compõem um conjunto de condições crônicas que em geral estão relacionadas a causas múltiplas e apresentam curso clínico que muda ao longo do tempo, com possíveis períodos de agudização, podendo gerar incapacidades.
Alessandra Sant'Anna Nunes +1 more
doaj +1 more source
Advanced Science, EarlyView.This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun +23 more
wiley +1 more source
Advanced Science, EarlyView.The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao +10 more
wiley +1 more source
Arthritis and Allied Conditions. A Textbook of Rheumatology [PDF]
, 1961 O. Savage
openalex +1 more source
Advanced Science, EarlyView.Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun +10 more
wiley +1 more source