Results 161 to 170 of about 396,895 (313)

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Supplementum 217: Annual Meeting of the Swiss Society of Rheumatology (Interlaken, Switzerland, August 25-26, 2016).

Swiss Medical Weekly
Swiss Society of Rheumatology
doaj   +1 more source

Consensus statements on the transition care for adolescents with rheumatic diseases in Saudi Arabia. [PDF]

Ther Adv Musculoskelet Dis
Nashawi M, Alahmari H, Basahl E, Alsulaim T, Alhamed A, Mirza A, Hafiz W, Mukhtar D, Aljaser A, Rayes HA, Albader H, Alqanatish J, Alsufyani K, Alderaan K, Majeed M, Somaily M, Altowijry M, Attar M, Olfat M, Omair MA, Alessi M, Al-Mayouf SM, Alzahrani Z, Al Ghanim N, Almutairi A, Alsuwairi W.   +25 more
europepmc   +1 more source

Clinical Rheumatology [PDF]

Annals of the Rheumatic Diseases, 1958
openaire   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Differences in Self-Reported Medication Nonadherence and Its Drivers in Young Adults Versus Older Adults With Systemic Lupus Erythematosus. [PDF]

J Rheumatol
Concannon HR, Sun K, Rogers JL, Clowse MEB, Randell RL, Maheswaranathan M, Criscione-Schreiber LG, Harris NJ, Eudy AM, Sadun RE.   +9 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Supplementum 188: Abstracts of the Annual meeting of the Swiss Society of Rheumatology

Swiss Medical Weekly, 2011
Swiss Society of Rheumatology
doaj   +1 more source

Editorial: Hereditary Periodic Fevers and Autoinflammatory Diseases

Frontiers in Pediatrics, 2022
Hafize Emine Sönmez, Betül Sözeri, Nuray Aktay Ayaz   +2 more
doaj   +1 more source

Single-center experience of voclosporin use for pediatric lupus nephritis: a case series. [PDF]

Rheumatology (Oxford)
Hazan R, Tang Civilibal N, Baszis K, Bigley TM.   +3 more
europepmc   +1 more source