Results 171 to 180 of about 202,977 (306)

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

open access: yesArthritis &Rheumatology, EarlyView.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino   +16 more
wiley   +1 more source

Tissue‐resident CD69+CXCR6+ Natural Killer cells with exhausted phenotype accumulate in human non‐small cell lung cancer

open access: yesEuropean Journal of Immunology, Volume 52, Issue 12, Page 1993-2005, December 2022., 2022
This study identified a CD69+CXCR6+ tissue‐resident NK (trNK) subset specifically accumulated in the tumor microenvironment of human non‐small cell lung cancer patients. CD69+CXCR6+ trNK cells showed an immunomodulatory‐like and exhaustion phenotype, and secreted IFN‐γ and TNF‐α rapidly. Abstract Natural killer (NK) cells with tissue‐residency features
Xiaoke Chen   +10 more
wiley   +1 more source

Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling

open access: yesArthritis &Rheumatology, EarlyView.
Objective Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments. Methods Plasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included
Robert T. Maughan   +15 more
wiley   +1 more source

Flt3L, LIF, and IL‐10 combination promotes the selective in vitro development of ESAMlow cDC2B from murine bone marrow

open access: yesEuropean Journal of Immunology, Volume 52, Issue 12, Page 1946-1960, December 2022., 2022
In vitro culture of murine bone marrow cells in Flt3L + LIF + IL‐10 promotes CD11b+ ESAMlow cDC2B subset generation from CDP but blocks cDC1 and pDC development. Flt3L alone or combined does not induce cDC2A generation in vitro. Abstract The development of two conventional dendritic cells (DC) subsets (cDC1 and cDC2) and the plasmacytoid DC (pDC) in ...
Laura Cyran   +8 more
wiley   +1 more source

Multimorbidity in psoriasis as a risk factor for psoriatic arthritis: a population-based study. [PDF]

open access: yesRheumatology (Oxford)
Karmacharya P   +11 more
europepmc   +1 more source

Book Review: Rheumatology [PDF]

open access: bronze, 1984
Douglas N. Golding
openalex   +1 more source

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