Results 31 to 40 of about 396,895 (313)

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V, Hermansson, M, Heron, C, Kiely, P, Sofat, N, Wajed, J   +5 more
core   +2 more sources

Predictors and outcomes of sustained, intermittent or never achieving remission in patients with recent onset inflammatory polyarthritis:Results from the Norfolk Arthritis Register [PDF]

, 2016
Objectives: Early remission is the current treatment strategy for patients with inflammatory polyarthritis (IP) and RA. Our objective was to identify baseline factors associated with achieving remission: sustained (SR), intermittent (IR) or never (NR ...
Cook, Michael J, Diffin, Janet, Lunt, Mark, MacGregor, Alex J, Scirè, Carlo A, Symmons, Deborah P M, Verstappen, Suzanne M M   +6 more
core   +1 more source

Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae [PDF]

, 2019
© 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium ...
Ferguson, Eamonn, James, Richard J E, Kiely, Patrick D W, McWilliams, Daniel F, Rahman, Shimin, Walsh, David A, Young, Adam   +6 more
core   +3 more sources

A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies [PDF]

, 2011
Objectives: The paediatric idiopathic inflammatory myopathies (IIMs) are a group of rare chronic inflammatory disorders of childhood, affecting muscle, skin and other organs.
Bohan, Bohan, Brown, Chinoy, Chinoy, Christen-Zaech, Clarissa A. Pilkington, Constantin, Elst, Gunawardena, Gunawardena, Huber, Huber, Huber, Huber, Isenberg, Joyce E. Davidson, Kevin Murray, Kim, Li, Li, Lovell, Lowry, Lucy R. Wedderburn, Maillard, Maillard, Marhaug, McCann, McCann, McCann, Mendez, Miller, Neil Martin, Pachman, Pachman, Petra Krol, Ravelli, Rider, Rider, Rider, Rider, Riley, Riley, Sally Smith, Salomonsson, Stringer, Symmons, Varsani, Wedderburn, Wedderburn, Wedderburn   +50 more
core   +1 more source

A novel electronic patient-reported outcome delivery system to implement health-related quality of life measures in routine clinical care: An analysis of 5 years of experience

Frontiers in Digital Health, 2023
ObjectiveTo develop a simple and secure technological solution to incorporate electronic patient-reported outcomes (ePROs) into routine clinical care.MethodsA novel ePRO questionnaire delivery system was developed by Software for Specialists (S4S) in ...
Kathleen Tymms, Catherine O'Sullivan, Tegan Smith, Geoffrey Littlejohn, Geoffrey Littlejohn, Tim Freeman, David Hoffman, Dana Segelov, Hedley Griffiths, Hedley Griffiths, Sabina Ciciriello, Sabina Ciciriello, Peter Youssef, Peter Youssef, Peter Youssef, David Mathers, David Mathers, Claire T Deakin   +17 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spondyloarthritides: Theories and beyond

Frontiers in Pediatrics, 2022
Spondyloarthritides (SpA) are a family of interrelated rheumatic disorders with a typical disease onset ranging from childhood to middle age. If left untreated, they lead to a severe decrease in patients' quality of life.
Begüm Kocatürk, Zeynep Balık, Gaye Pişiren, Umut Kalyoncu, Füsun Özmen, Seza Özen   +5 more
doaj   +1 more source

The Scope and Scale of Clinical Research Accomplished by Rheumatologists Early in Their Careers [PDF]

, 2009
[Excerpt] The scope and scale of clinical research is unknown for any medical or surgical specialty beyond snap shots of the broad aims and expenditures of research programs sponsored by federal agencies or the pharmaceutical industry.
Desjardins, Claude, Ehrenberg, Ronald G, St. Clair, E. William, M.D.   +2 more
core   +1 more source

Rheumatological Quatrains

Indian Journal of Rheumatology, 2023
The practice of rheumatology, at times, deserves newer perspective expressed through narrative tools like poetry.[1] Quatrain, a stanza, is complete poem in four lines whereas Japanese “haiku” is small poem consisting of three lines in its purest form.[2] The verses here are convenient amalgamation of the above two forms. These are inspired by haiku in
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source