Results 51 to 60 of about 59,753 (258)

Impact of China's National Volume‐Based Procurement Policy on Cost, Volume, and Market Structure: An Interrupted Time‐Series Analysis of Montelukast Sodium

Health Care Science, EarlyView.
Using ARIMA‐based interrupted time‐series analysis, this study reveals that China's NVBP policy significantly reduced daily costs and enhanced affordability, driving generic substitution and the elimination of low‐quality products. Additionally, non‐winning manufacturers adopted strategic pricing behaviors to segment the market.
Yufei Cheng, Fanyu Liu, Yongyi Wu, Siyu Liu, Xiaohan Fan, Bin Jiang, Zhao Yang   +6 more
wiley   +1 more source

Applying Change Models and Methods During a Period of Vast Digital Transformation: A Systematic Review of Practice in Healthcare

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Introduction Reflection and learning about the use of virtual care in healthcare delivery has become a central goal for health systems internationally. Insights drawn in the aftermath of the COVID‐19 pandemic have led to vast changes to embed virtual care in health care delivery. This study explored the methodologies used to manage change that
Rebecca McDonnell, Ashfaq Chauhan, Corey Adams, Alexander Cardenas, Michelle Moscova, Ramya Walsan, Maryam Sina, Alice Munro, Elizabeth Manias, Rebecca Mitchell, Anthony Gust, Sabe Sabesan, Reema Harrison   +12 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Prevalence of allergic rhinitis, and symptoms as indicators of risk in schoolchildren of the Puebla Northern Mountain Range

Revista Alergia México, 2018
Background: According to the ISAAC study, the prevalence of allergy disease is reported to have increased. Objective: To determine the prevalence of allergic rhinitis diagnosis, its symptoms and the magnitude of the association of symptoms with the ...
Eleazar Mancilla-Hernández, Evaristo González-Solórzano   +1 more
doaj   +1 more source

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy

iMeta, EarlyView.
Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen‐specific immune tolerance. Here, we developed an oral nano‐dietary fiber (NDF) platform that integrates allergen delivery with microbiota‐driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for ...
Yuting Qin, Zeming Wang, Yuru Zong, Zefang Lu, Junxiu Liu, Ruifang Zhao, Guangjun Nie, Hanqing Chen   +7 more
wiley   +1 more source

Allergic Rhinitis in Women [PDF]

Women's Health, 2007
Allergic rhinitis is a high-prevalence disease that significantly impairs the quality of life. Its pathogenesis is quite well understood, and involves numerous cells, cytokines and mediators, which result in an inflammatory process. The triggering IgE-mediated reaction does not differ between men and women, but in females some aspects, related mainly ...
openaire   +4 more sources

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Clinical progress note: Rotavirus

Journal of Hospital Medicine, EarlyView.
Abstract Rotavirus is a vaccine‐preventable cause of acute, viral gastroenteritis typically characterized by diarrhea, vomiting, and fever. Prior to rotavirus vaccine introduction, nearly all children worldwide had been infected by 5 years of age. Severe rotavirus gastroenteritis causes dehydration and electrolyte derangements, and infants and young ...
Kelsey Thetford, Meghan Hofto
wiley   +1 more source

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source