Results 221 to 230 of about 110,979 (314)

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis. [PDF]

Front Immunol
Yan S, Xue K, Wang Y, Jia D, Chen Y, Lai X, Zhao C, Chen G, Xu Y, Wang X, Pan H, Zeng N.   +11 more
europepmc   +1 more source

Rheumatoid arthritis and airway hyperresponsiveness: A GWAS-based mendelian randomization study. [PDF]

Medicine (Baltimore)
Shu H, Wang Y, Shen R, Qian C, Anniwaer A, Ling X, Zhu X, Shen H, Zhang Q.   +8 more
europepmc   +1 more source

Th9 and IL9 in Chronic Superior Airway Inflammation: A Narrative Review. [PDF]

Biomedicines
Dumitru M, Berghi O, Musat G, Serboiu C, Oancea A, Berghi AG, Zamfir-Chiru-Anton A, Vrinceanu D.   +7 more
europepmc   +1 more source

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Efficacy predictions for omalizumab treatment based on basophil CD203c expression in patients with allergic rhinitis by basophil activation test -- a real-life, pilot study. [PDF]

World Allergy Organ J
Zhao Z, Chen H, Liu T, Hong J, Deng Y, Hua Q.   +5 more
europepmc   +1 more source

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations

Allergy, EarlyView.
Little is known about the factors driving AIT prescription in clinical practice, including the level of personalization from patient to patient. Patient‐centred factors theoretically would favour SLIT prescription. Doctors’ knowledge, training, and country influence the final decision on the route.
Carmen Vidal, Davide P. Caimmi, Pablo Rodriguez del Rio, Óscar Lado‐Baleato, Francisco Gude, Pilar Rico‐Nieto, Thomas B. Casale, Jorge A. Aguilar, Maryam Ali Al‐Nesf, Fatima Ashkanani, Adeeb Bulkhi, Juan C. Cardet, Claudia Almendarez, Silvia Caimmi, Iván Cherrez, Enza D’Auria, Stephanie Dramburg, Motohiro Ebisawa, Naoko Fusayasu, Maximiliano Gomez, Sandra Gonzalez‐Diaz, Carla Irani, Andrey Kamaev, Connie Katelaris, Narinder Kaur, Oksana KurBacheva, José I. Larco, Désirée Larenas‐Linnemann, Margaret Li, Olga Patricia Monge‐Ortega, Pablo Moreno, Oliver Pfaar, Cesar F. Pozo‐Beltrán, Marta E. Rubio, Jorge Sanchez, Giovanni Sedo, Silvia Uriarte, Lin Yang, Hao Chen, Rongfei Zhu, Pascal Demoly, Moises A. Calderon, on behalf of the CHOICE‐Global Survey Team   +42 more
wiley   +1 more source

Allergic rhinitis and nasal septum deviation in children: cause, consequence, or bidirectional relationship? Insights from the ARHINASD study. [PDF]

Front Med (Lausanne)
Carucci L, Nocerino R, Cantone E, Berni Canani F, Licito M, La Marca L, Farnetano M, Masino A, Oglio F, Marziali D, Coppola S, Berni Canani R.   +11 more
europepmc   +1 more source