Results 181 to 190 of about 63,147 (208)
Some of the next articles are maybe not open access.
Structure of Gα q -p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs
Science, 2007The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide–binding protein (G protein) Gα q and thereby links Gα q -coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA ...
Susanne, Lutz +10 more
openaire +2 more sources
RhoA-Mediated Signaling in Mechanotransduction of Osteoblasts
Connective Tissue Research, 2012Osteoblasts play a pivotal role in load-driven bone formation by activating Wnt signaling through a signal from osteocytes as a mechanosensor. Osteoblasts are also sensitive to mechanical stimulation, but the role of RhoA, a small GTPase involved in the regulation of cytoskeleton adhesion complexes, in mechanotransduction of osteoblasts is not ...
Kazunori, Hamamura +6 more
openaire +2 more sources
The role of RhoA in corticogenesis
2012Insights into the developmental processes during which the brain forms from the neuroepithelium may provide a deeper understanding how the brain works. The Rho family of small GTPases is known for its many cell biological functions such as regulation of the cytoskeleton, gene expression, cell migration, adhesion, cell polarity and the cell cycle.
openaire +1 more source
Degradation of RhoA by Smurf1 Ubiquitin Ligase
2006The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. We found that Smurf1, a HECT domain E3 ubiquitin ligase, could specifically target RhoA but not Cdc42 or Rac1 for degradation.
Hong-Rui, Wang +5 more
openaire +2 more sources
Macrophages and RhoA Pathway in Transplanted Organs
2017RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages.
Liu, Yianzhu +4 more
openaire +2 more sources
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
Neuron, 2021Brett J Hilton +2 more
exaly