Results 171 to 180 of about 63,147 (208)

Regulation of RhoA GTPase and various transcription factors in the RhoA pathway

Journal of Cellular Physiology, 2018
RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular morphology, and migration along with various proliferation and transcriptional activity in cells. RhoA activity is regulated by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and the guanine
Rokibul Islam, Jae-Bong Park
exaly   +3 more sources

Redox Regulation of RhoA

Biochemistry, 2006
We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo, Kimberly W, Raines, Viorel, Mocanu, Sharon L, Campbell   +3 more
openaire   +2 more sources

P53 in RhoA regulation

Cytoskeleton, 2020
AbstractRecent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network.
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Inhibition of RhoA by p120 catenin

Nature Cell Biology, 2000
RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the formation of adherens junctions. The catenin p120 has also been implicated in cadherin clustering through an unknown mechanism.
P Z, Anastasiadis, S Y, Moon, M A, Thoreson, D J, Mariner, H C, Crawford, Y, Zheng, A B, Reynolds   +6 more
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RhoA and resistance artery remodeling

American Journal of Physiology-Heart and Circulatory Physiology, 2005
Resistance arteries are able to adapt to physiological and pathophysiological stimuli to maintain adequate perfusion according to the metabolic demand of the tissue. Although vasomotor control allows rapid adaptation of lumen diameter, vascular remodeling constitutes an active process that occurs in response to long-term alterations of hemodynamic ...
Gervaise, Loirand, Malvyne, Rolli-Derkinderen, Pierre, Pacaud   +2 more
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Expression of RhoA in placenta of preeclampsia

Journal of Huazhong University of Science and Technology, 2006
In order to detect the expression of RhoA in placenta from normal pregnancy and preeclampsia and evaluate the role of RhoA in preeclampsia, the expression of RhoA in placenta collected from 40 preeclampsia patients and 20 normotensive controls was determined by immunohistochemistry and RT-PCR. RhoA was found in syncytiotrophoblasts and cytotrophoblasts.
Li, Zhou, Fuyuan, Qiao
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Inactivation of RhoA for Hypertension Treatment Through the TRPV4–RhoA–RhoGDI1 Axis

Circulation
BACKGROUND: The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and ...
Jiawen Wang, Zhen Yuan, Na Yu, Qian Jiao, Honglei Zhou, Wenjie Liao, Jiwei Shan, Shanshan Ruan, Yi Zhao, Ya Mo, Luyao Qi, Tiejun Li, Jianjun Fu, Bowen Ke, Yufang Xu, Xuhong Qian, Jian Zhang, Zhenjiang Zhao, Shiliang Li, Rui Wang, Honglin Li   +20 more
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Activated RHOA and peripheral axon regeneration

Experimental Neurology, 2008
The regeneration of adult peripheral neurons after transection is slow, incomplete and encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been examined in this context. We examined the expression, activity and functional role of RHOA GTPase and its ROK effector, inhibitors of regeneration, during peripheral axon outgrowth.
C, Cheng, C A, Webber, J, Wang, Y, Xu, J A, Martinez, W Q, Liu, D, McDonald, G F, Guo, M D, Nguyen, D W, Zochodne   +9 more
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RhoA

1995
Abstract Rho sequences were originally isolated from an Aplysia cDNA library and used to identify three distinct, but highly homologous human sequences (Madaule and Axel 1985). The complete sequence of one of these, RhoA (originally called clone 12) (Yeramian et al. 1987), is shown in Fig. 1. The GenBank accession number is X05026.
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