Results 151 to 160 of about 52,817 (240)

Exosomal lncRNA SILC1 from bicalutamide-activated mesenchymal stem cells promotes prostate cancer survival and bicalutamide resistance via the miR-577/RHOA axis. [PDF]

J Transl Med
Yu J, Liang H, Lu D, Pham TH, Mo Q, Hussein MB, Wen J, He Q, Li Y, Wei F, Yang G, Yan X, Liao N, Wei L, Cui Z, Chen H, Qin M, Wang F, Cheng J.   +18 more
europepmc   +1 more source

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

RhoB supports rubella infection and impairs endothelial barrier integrity through downstream ROCK signaling. [PDF]

Cell Commun Signal
Kovacevic I, Müller M, Mair L, Henschke V, Kowalski A, Boeckel JN, Kropf K, Posern G, Reibetanz U, Claus C.   +9 more
europepmc   +1 more source

Engineering Piezo1‐Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Cell‐derived extracellular vesicles (EVs) are promising nanocarriers for therapeutic delivery platforms owing to their biocompatibility and capacity to protect and efficiently transport bioactive molecules. However, EV‐based therapeutics remain constrained by inefficient cargo loading and low production yields, which limit scalable ...
Najla A. Saleh, Rozita Shafiq, Amanda P. Cicerone, Sadhana Kilangodi, Hayden Hartwig, George I. Mias, Guangqing Lu, Jun R. Huh, Weiping Li, Cheri X. Deng, Masamitsu Kanada   +10 more
wiley   +1 more source

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review). [PDF]

Oncol Rep
Daher A, Assi Z, Kanaan A, Al Khatib A, El Sibai M.   +4 more
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Protocol to identify covalent inhibitors targeting RhoA Cys16. [PDF]

STAR Protoc
Koo TY, Ho CS, Yip HY, Chung CY.
europepmc   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

PIP5K1A-PIP2-RhoA Signaling Orchestrates Membrane Remodeling during Early Porcine Embryo Development. [PDF]

Int J Biol Sci
Zhan CL, Lee SH, Nie ZW, Cui XS.
europepmc   +1 more source

A simple probabilistic AlphaFold interaction score

Protein Science, Volume 35, Issue 9, September 2026.
Abstract AlphaFold has enabled large‐scale prediction of protein–protein and protein–nucleic acid complexes, but ranking and assessing the quality of predicted models remain challenging. Existing confidence scores are often highly parametrized and provide limited interpretability.
Mihaly Badonyi, Agnes Toth‐Petroczy
wiley   +1 more source