Results 131 to 140 of about 52,817 (240)

RhoA deficiency in chondrocyte inhibits cartilage fibrosis and ameliorates osteoarthritis progression via SOX4/MMP2 axis. [PDF]

J Orthop Translat
Xu Y, Xu S, Li J, Wang S, Liang J, Wang J, Wang X, Deng G, Zhu L, Guo J.   +9 more
europepmc   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity. [PDF]

J Cell Biol
Hayase J, Yang L, Zhou YH, Wang K, Xu CR, Bi E.   +5 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

AH001: A New Drug Targeting RhoA in Heart Failure. [PDF]

Circ Res
Nguyen VB, Kapiloff MS.
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Acidosis Regulates Microtubule Dynamics via the β1 Integrin/RhoA/CRMP-2 Axis. [PDF]

J Am Chem Soc
Lachowski D, Cortes E, Mykuliak V, Fernandez-de la Torre M, Bastida Urkiza A, Muñoz-Barrutia A, Garcia-Gonzalez D, Hytönen V, Del Rio Hernandez A.   +8 more
europepmc   +1 more source

RHOA wt Allele [PDF]

, 2020
openaire   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Rho GTPases in cancer resistance: mechanisms, vulnerabilities, and therapeutic opportunities. [PDF]

Biochem Soc Trans
Beaudin A, Lefrançois P, Laurin M.
europepmc   +1 more source