Results 111 to 120 of about 63,147 (208)

Simvastatin disrupts the RhoA pathway.

, 2016
The Rho/Rho-associated kinase pathway activity is elevated in endothelial monolayers with increased matrix stiffness but is attenuated with 10 μM simvastatin treatment.
John Huynh (704557), Cynthia A. Reinhart-King (218276), Courtney J. Faber (845610), Marsha C. Lampi (845609), Matthew R. Zanotelli (845611), Francois Bordeleau (5666464)   +5 more
core   +1 more source

Quantitative comparison of RhoA-TcdB contacts.

, 2012
aStructure of RhoA docked to the most open normal mode of TcdB.bStructure of closest Thr37-Mn approach within NM-RhoA MD simulation.cStructure of representative frame from the most populated cluster of the NM-RhoA MD simulation.
G. Andrés Cisneros (149251), Rebecca Swett (149249), Andrew L. Feig (149253)   +2 more
core   +1 more source

Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma

Blood Advances
: The RHOA G17V mutation is highly recurrent in T follicular helper (TFH) cell lymphoma of the angioimmunoblastic type (AITL; 60%-70% of cases) and frequently associated with mutations in other T-cell receptor signaling genes, including CD28.
David Vallois, Mélanie Juilland, Kalliopi Ioannidou, François Lemonnier, Edoardo Missiaglia, Bettina Bisig, Margot Thome, Laurence de Leval   +7 more
doaj   +1 more source

p27^kip1 interacts with RhoA.

, 2013
(A) p27kip1 was immuno-precipitated from K562 cells and CD34+ cells of chronic phase CML followed by detection of RhoA in the resulting immuno-precipitate by western blotting.
Lakshmishri Lahiry (465368), Malay Ghosh (465370), Debasis Banerjee (465369), Anita Roy (465367), Subrata Banerjee (465371)   +4 more
core   +1 more source

CTHRC1 activates RhoA activity.

, 2013
(A) Pull-down assay of Rho family proteins showed that knockdown of CTHRC1 inhibited the activation of RhoA, but not Rac1 or Cdc42. (B) Treating Huh7 cells with recombinant CTHRC1 (100 ng/ml) activated the RhoA pathway.
Yu-Ling Chen (399126), Hey-Chi Hsu (52813), Yung-Ming Jeng (197758), Ting-Huang Wang (439324), Ray-Hwang Yuan (399127)   +4 more
core   +1 more source

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Molecular Cancer
Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Chenglong Ma, Ruocen Liao, Xingyu Chen, Qianhua Cao, Xinyue Deng, Zhijun Dai, Chenfang Dong   +6 more
doaj   +1 more source

RHOA Gene [PDF]

, 2020
openaire   +1 more source

Novel peptide recognized by RhoA GTPase

, 2006
A phage-displayed random 7-mer disulfide bridge-constrained peptide library was used to map the surface of the RhoA GTPase and to find peptides able to recognize RhoA switch regions. Several peptide sequences were selected after four rounds of enrichment,
Oleksy, Arkadiusz, Otlewski, Jacek, Drulis-Fajdasz, Dominika, Jelen, Filip   +3 more
core  

DIFFERENTIAL RHOA ACTIVITY IN CHONDROCYTES UNDER FLOW

, 2012
poster abstractMechanical force environment is a major factor that influences cellular homeostasis and remodeling. The prevailing wisdom in this field demon-strated that a threshold of mechanical forces or deformation was required to affect cell ...
Na, Sungsoo, Yokota, Hiroki, Wan, Qiaoqiao   +2 more
core   +1 more source

Non-canonical and constitutive activation of small GTPases: more than an exception to the rule? [PDF]

Biochem J
Kiers J, Hordijk PL.
europepmc   +1 more source