Results 91 to 100 of about 63,147 (208)
Journal of Pharmacological Sciences, 2010 .: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of experimental ...
Yoshihiko Chiba, Miwa Misawa
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Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cells
, 2019 Xuping Wu,1 Ting Yan,2 Leiyu Hao,3 Yichao Zhu3,41The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing 210003, People’s Republic of China; 2Safety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of ...
Zhu Y, Hao L, Yan T, Wu X
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Regulation of ROCKI by tyrosine phosphorylation
, 2010 RhoA-regulated cell contractility plays important roles in variety of cellularrocesses. Rho-associated coiled–coil kinase (ROCK) is one of the downstreamffectors of RhoA signaling and generates cell contraction force by promoting myosinight chain (MLC ...
Jhong, Jheng-Guang, 鍾政光
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Serine Phosphorylation Negatively Regulates RhoA in Vivo
, 2003 Previous work indicates that RhoA phosphorylation on Ser188 by cAMP or cGMP-dependent kinases inhibits its activity. However, these studies lacked the possibility to directly study phosphorylated RhoA activity in vivo. Therefore, we created RhoA proteins
Wennerberg, Krister +2 more
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RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia
Frontiers in Molecular Neuroscience, 2012 RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie +5 more
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Functional validation of RHOA.
, 2012 (A) HMGCR and RHOA levels were quantified in 480 CAP LCLs after 24 hour incubation with 2 µM activated simvastatin or sham buffer. HepG2 (n = 12) and Huh7 cells (n = 6) cells were reverse transfected with Silencer Select siRNAs specific for RHOA or a ...
Yu-Lin Kuang (121417) +7 more
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Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways.
RhoA plays a crucial role in neuronal polarization, where its action restraining axon outgrowth has been thoroughly studied. We now report that RhoA has not only inhibitory but also a stimulatory effect on axon development depending on when and where ...
Bisbal, Mariano +11 more
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, 2017 The role of L-type Ca2+ channels (LTCCs) and RhoA/Rho kinase (ROCK) on depolarization-induced sustained arterial contraction lasting several minutes is already known.
Ureña, Juan +7 more
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Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]
, 2010 In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
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Neoplasia: An International Journal for Oncology Research, 2008 RhoA is a critical signaling molecule regulating a variety of cellular processes, such as cytoskeletal organization, adhesion, and apoptosis. It is recently considered responsive to reactive oxygen species (ROS). Nevertheless, how RhoA regulates anoikis,
Jun Cai +7 more
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