Results 101 to 110 of about 63,147 (208)
, 2013 RhoA為小GTP水解酶裡Rho蛋白質家族成員之一，它調控多種的細胞行為，包括細胞移動、分化、細胞週期的前進，和基因的轉錄；就像大部分的GTP水解酶，RhoA循環在活化態 (和GTP結合) 和非活化態 (和GDP結合) 之間，並且只有活化態的RhoA可以作用於下游受器蛋白，由於RhoA的活性受到多種調控機制進行動態控制，因此偵測活體細胞裡RhoA在時間及空間上活性的動態分布以及偵測細胞萃取液中RhoA活性的高低是非常重要的。 在本研究中，我在一段胜肽上接上了靈敏於環境改變的螢光分子 ...
Chen, Chen-Cheng, 陳振誠
core
Untangling the role of RhoA in the heart: protective effect and mechanism
Cell Death and DiseaseRhoA (ras homolog family member A) is a small G-protein that transduces intracellular signaling to regulate a broad range of cellular functions such as cell growth, proliferation, migration, and survival.
Shigeki Miyamoto
doaj +1 more source
MK-STYX decreases RhoA activation.
, 2014 (A) PC12 cells were transfected with pMT2 or pMT2-FLAG-MK-STYX-FLAG. 24 hr post-transfection cells were stimulated with 100 ng/ml NGF, and lysed at the indicated time points. Activation of RhoA was quantified by RhoA G-LISA small G-protein assay.
Alexander G. McFarland (670488) +6 more
core +1 more source
RhoA activity in MAT-induced cells
, 2020 Total RhoA and GTP-bound RhoA (separated by pulldown with GST-rhotekin) were detected with immunoblotting using anti-RhoA antibody. Fold change values (treated vs.
Vladimír Čermák (8690414) +2 more
core +1 more source
, 2016 (A-C) RhoA+/+ platelets (A), RhoA+/+ platelets with Rhosin (30 μM, B) or RhoA-/- platelets (C) were layered over fibrinogen (3 μg/ml) coated cover slips in the presence of apyrase (3 U/ml) for five min.
Yi Zheng (113896) +4 more
core +1 more source
Association between RHOA haplotypes and expression of RHOA exon 2.5.
, 2012 (A) RHOA gene structure and location and sequence of exon 2.5. The 5′ and 3′ UTRs are indicated in solid grey, canonical exons are outlined in grey, and the novel exon is shown in red. The location of the three common RHOA exonic SNPs are shown.
Yu-Lin Kuang (121417) +7 more
core +1 more source
Cell Death and DiseaseRhoA, a small GTPase, plays a pivotal role in various diseases, including spinal cord injury (SCI). Although RhoA inhibition has been traditionally viewed as beneficial for SCI repair, recent clinical trials of RhoA inhibitors in SCI have failed to show ...
Jiale Cai +12 more
doaj +1 more source
Angiotensin II Activates the RhoA Exchange Factor Arhgef1 in Humans
, 2015 International audienceAlthough a causative role for RhoA-Rho kinase has been recognized in the development of human hypertension, the molecular mechanism(s) and the RhoA guanine exchange factor(s) responsible for the overactivation of RhoA remain unknown.
Blanchard, Anne +8 more
core +1 more source
Cell-Instructive Alginate Hydrogels Targeting RhoA
, 2018 Cellular processes involve dynamic rearrangement of the cytoskeleton. The GTPase RhoA plays a fundamental role in controlling cytoskeletal architecture.
Marcy Zenobi-Wong (116962) +7 more
core +1 more source
RhoA accelerates atherosclerosis progression by interacting with Hspa5
Scientific ReportsRhoA has been demonstrated to play a role in atherosclerosis (AS); however, its regulatory mechanisms remain poorly characterized. This study aimed to investigate the function of RhoA in AS and elucidate its underlying mechanisms.
Ruoyu Dong +5 more
doaj +1 more source