Results 101 to 110 of about 600,349 (302)

An application of deep learning model InceptionTime to predict nausea, vomiting, diarrhoea, and constipation using the gastro-intestinal pacemaker activity drug database (GIPADD)

Scientific Reports
The accurate preclinical prediction of adverse drug reactions (ADRs), such as nausea and vomiting, remains a challenge. The Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD) ( http://www.gutrhythm.com/public_database ) is a new source of ...
Hephaes Chuen Chau, Julia Yuen Hang Liu, John Anthony Rudd   +2 more
doaj   +1 more source

phase shifting the erg amplitude circadian rhythm of juvenile crayfish by caudal monochromatic illumination

, 1996
The objective of the present work was to determine the physiological mechanisms underlying the synchronization of the ERG amplitude rhythm. Chronic ERG recordings were obtained from juvenile instars of crayfish.
Fanjul, ML, Miranda-Anaya, M, Bernal-Moreno, JA   +2 more
core  

Visualizing Levels of Rhythmic Organization [PDF]

, 2007
Wagner P. Visualizing Levels of Rhythmic Organization. In: XVIth International Congress of the Phonetic Sciences, Saarbrücken, 6-10 August 2007. 2007: 1113-1116.The paper presents a method to visualize the timing related levels of prosodic organization ...
Wagner, Petra ; https://orcid.org/
core  

Ventricular rate regularization with right ventricular septal pacing preserves left ventricular function and improves exercise capacity in patients with permanent atrial fibrillation

, 2008
29th Annual Scientific Session of the Heart Rhythm Society, San Francisco, CA, USA, 14–17 May 2008. In Heart Rhythm, v. 5 n. 5(Suppl.), p. S187, abstract no.
Ho, WY, Tse, HF, Lau, CP, Kwok, KW, Siu, DCW, Tang, MO   +5 more
core   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Rhythm and Balance in Sculpture and Poetry

, 2013
Rhythm might stand for the contrast between balance and movement, rest and conflict, in a piece of art. In this paper, we show that rhythm works as an organizing power as well as a producer of meaning. Both characteristics relate to the fact that rhythms
Lilja, Eva,, Hopsch, Lena,
core  

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Precision patient selection for ablate-and-pace: a multi-center study comparing leadless pacemaker vs. standard pacemaker in patients with indication to ablate-and-pace for atrial fibrillation (LEAD-AP)

Frontiers in Cardiovascular Medicine
BackgroundIn patients with symptomatic permanent atrial fibrillation (AF) who are not candidates for rhythm control, atrioventricular node (AVN) ablation followed by ventricular pacing “ablate-and-pace” offers reliable rate control and symptom relief ...
Ingrid Overeinder, Luigi Pannone, Domenico Laviola, Wael Zaher, Wael Zaher, Giacomo Mugnai, Gianmarco Arabia, Ivan Eltsov, Ioannis Doundoulakis, Domenico Giovanni Della Rocca, Paul-Adrian Calburean, Vedran Pašara, Ludovica Carmagnola, Tommaso Sattin, Antonio Sorgente, Alvise Del Monte, Giacomo Talevi, Gezim Bala, Alexandre Almorad, Erwin Ströker, Juan Sieira, Ali Gharaviri, Mark La Meir, Pedro Brugada, Andrea Sarkozy, Gian Battista Chierchia, Antonio Curnis, Serge Boveda, Serge Boveda, Carlo de Asmundis   +29 more
doaj   +1 more source

Circadian rhythm of wrist temperature and night shift-work

, 2015
The stability of the circadian rhythms, especially regarding their amplitude and phase relationship, is a major factor for health. Shift-work and working night shifts are known to be associated with a variety of health problems caused, at least partially,
Miguel, MAL, De Martino, MMF, Ferreira, LRC, Menna-Barreto, L   +3 more
core   +1 more source