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Ribavirin: A clinical overview [PDF]
European Journal of Epidemiology, 1986 Ribavirin, a broad spectrum, non-interferon-inducing virustatic chemotherapeutic agent, demonstrates activity against a wide range of RNA and DNA viruses, including the retrovirus known to cause the acquired immune deficiency syndrome. The drug's proposed mechanism of action, as well as pharmacokinetics are discussed, and preclinical toxicity, safety ...
R Smith, G Banks, H Fernandez
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Pediatrics, 1987
Immunization has proved to be the most effective way of controlling viral diseases, and the development of antiviral drugs has lagged behind the development of antibacterial agents. Many of the early antiviral agents were DNA nucleoside analogs such as idoxuridine, cytarabine, and vidarabine, which competitively inhibited replication of DNA viruses ...
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Immunization has proved to be the most effective way of controlling viral diseases, and the development of antiviral drugs has lagged behind the development of antibacterial agents. Many of the early antiviral agents were DNA nucleoside analogs such as idoxuridine, cytarabine, and vidarabine, which competitively inhibited replication of DNA viruses ...
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Clinics in Liver Disease, 2009
Ribavirin is ineffective against hepatitis C virus as mono-therapy but is critical in attaining both early virologic response and sustained virologic response when combined with pegylated interferon. Ribavirin has significant dose-limiting toxicities, the most important of which is hemolytic anemia.
William W, Shields, Paul J, Pockros
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Ribavirin is ineffective against hepatitis C virus as mono-therapy but is critical in attaining both early virologic response and sustained virologic response when combined with pegylated interferon. Ribavirin has significant dose-limiting toxicities, the most important of which is hemolytic anemia.
William W, Shields, Paul J, Pockros
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Hemoglobinuria With Ribavirin Treatment
Journal of Clinical Gastroenterology, 2003Chronic hepatitis C virus is a major worldwide cause of hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinomas. Combination therapy of ribavirin with short- or long-acting interferon-alpha is now the standard treatment of chronic hepatitis C. This therapy is associated with a wide range of side effects.
Omar Massoud +2 more
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Drug Intelligence & Clinical Pharmacy, 1984
Despite the plethora of antibiotics available for the treatment of bacterial infections, very few agents have been developed to treat viral diseases. Ribavirin (Virazole) is a triazole nucleoside antiviral agent that produces selective antiviral effects against a broad spectrum of RNA and DNA viruses.
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Despite the plethora of antibiotics available for the treatment of bacterial infections, very few agents have been developed to treat viral diseases. Ribavirin (Virazole) is a triazole nucleoside antiviral agent that produces selective antiviral effects against a broad spectrum of RNA and DNA viruses.
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Ribavirin Aerosol in the Elderly
Chest, 1988Ribavirin aerosol is effective in treating respiratory syncytial virus and influenzal infections in children and young adults. It has not been studied in elderly patients. We evaluated the safety of ribavirin aerosol in eight elderly volunteers at high risk for influenza.
Howard P. Liss, Jack M. Bernstein
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Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Stewart W. Schneller, Meral Tuncbilek
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Stewart W. Schneller, Meral Tuncbilek
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PHOTOLABELING PROBES OF RIBAVIRIN AND EICAR [PDF]
Nucleosides, Nucleotides & Nucleic Acids, 2005 Ribavirin, the only small molecule available so far for treating hepatitis C virus infection, was recently used in an emergency context to treat patients with severe acute respiratory syndrome in the early stages of the disease. EICAR, one of the most potent congeners of ribavirin, has 10 to 100 times greater antiviral potency than ribavirin.
Jinqiao Wan +5 more
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Pediatrics, 1988
To the Editor.— The report by McMillan and colleagues1 of the nonpredictiveness of certain clinical and laboratory tests in determining the duration of hospitalization of patients with respiratory syncytial virus adds to our understanding of this important respiratory pathogen.
B, Dashefsky, E R, Wald, M, Green
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To the Editor.— The report by McMillan and colleagues1 of the nonpredictiveness of certain clinical and laboratory tests in determining the duration of hospitalization of patients with respiratory syncytial virus adds to our understanding of this important respiratory pathogen.
B, Dashefsky, E R, Wald, M, Green
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Acta Crystallographica Section A Foundations and Advances, 2022
Exhaustive characterisation of polymorphism and phase transitions in active pharmaceutical ingredients (APIs) is of critical importance to pharmaceutical companies in the development of ‘solid forms’ used in patient therapy. Polymorphs of the same API may differ in their physical properties e.g.
Tiwari, B., Giordano, N.
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Exhaustive characterisation of polymorphism and phase transitions in active pharmaceutical ingredients (APIs) is of critical importance to pharmaceutical companies in the development of ‘solid forms’ used in patient therapy. Polymorphs of the same API may differ in their physical properties e.g.
Tiwari, B., Giordano, N.
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