Results 141 to 150 of about 67,958 (288)

Ticagrelor modestly raises plasma riboflavin concentration in humans and inhibits riboflavin transport by BCRP and MRP4

Riboflavin (vitamin B2) has been proposed as a biomarker for breast cancer resistance protein (BCRP) activity. In recent studies in mice, cynomolgus monkeys, and humans, BCRP-inhibiting drugs increased the plasma concentration of riboflavin.
Hämäläinen, Kreetta, Deng, Feng, Niemi, Mikko, Neuvonen, Mikko, Lehtisalo, Minna   +4 more
core   +1 more source

Factors associated with the percentage of individuals who initiate and discontinue naltrexone as a relapse prevention pharmacotherapy in opioid use disorder: A systematic review, meta‐analysis and meta‐regression

Addiction, EarlyView.
Abstract Background and aims Naltrexone is a pharmacotherapeutic option for relapse prevention in opioid use disorder (OUD); however, studies highlight low rates of initiation and high rates of discontinuation as limiting its effectiveness. We aimed to (1) estimate the percentage of individuals with OUD who (having undergone withdrawal and wish to ...
Emmert Roberts, Elizabeth Sanderson, Thomas Santo Jr., Matthew Hickman, Michael Farrell, Louisa Degenhardt   +5 more
wiley   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Genome‐wide association and interaction analysis for proliferative retinopathy in adults with type 2 diabetes born during famine: The DOLCE study in Ukraine

Acta Ophthalmologica, EarlyView.
Abstract Purpose Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working‐age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown.
Olena Fedotkina, Most Champa Begum, Xuan Tung Trinh, Turkuler Özgumus, Mikael Åkerlund, Peter Nilsson, Leticia Maria Spindola, Valeriya Lyssenko   +7 more
wiley   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Microbial fermentation for riboflavin biofortification in African traditional fermented foods. [PDF]

NPJ Sci Food
Spano G, Russo P, Fragasso M.
europepmc   +1 more source

Functional Tooth Units, Oral Disease Status and Dietary Quality in a Representative US Population

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate how functional tooth units (FTUs) and oral conditions are associated with dietary quality through multidimensional measures within a unified analytic framework. Materials and Methods Data were drawn from 6291 adults in the 2011–2014 National Health and Nutrition Examination Survey.
Yu Xie, Mengning Bi, Xiaoyu Yu, Jie Shen, Hairui Li, Yuan Li, Andrea Roccuzzo, Changzheng Yuan, Maurizio S. Tonetti   +8 more
wiley   +1 more source

Elucidating the photo-induced fading mechanism in green tea beverages: Metabolomics-guided discovery, quantification, and spiking validation of critical metabolites. [PDF]

Food Chem X
Wang S, Li S, Tu Z, Tao M, Yu Q, Xu A, Cao Y, Liu Z.   +7 more
europepmc   +1 more source

Development of an Artificial Liquid Diet for Allelochemical Delivery in Lycorma delicatula

Journal of Applied Entomology, EarlyView.
ABSTRACT Spotted lanternfly, Lycorma delicatula White (Hemiptera: Fulgoridae), is an invasive phloem‐feeding planthopper native to Asia, which poses a growing threat to US agriculture due to its broad host range and rapid spread since its 2014 detection. To better understand how L.
Brian F. Ruether, Mariana Gelambi, Kate A. Burgiss, Alejandra Caballero, Sherry B. Hildreth, Dorothea Tholl   +5 more
wiley   +1 more source