Results 101 to 110 of about 21,043 (311)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Regulation of cytoplasmic RNA stability: lessons from drosophila [PDF]

, 2018
The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Abdelmohsen, Allmang, Ameres, An, Antic, Astuti, Baccarini, Bakheet, Bakheet, Bakheet, Bassett, Bazzini, Berezikov, Bitetti, Boczonadi, Bonneau, Bortolamiol-Becet, Braun, Brown, Burroughs, Cairrao, Cairrao, Callahan, Carballo, Chang, Chang, Chapman, Chapman, Cheadle, Chen, De Almeida, De Lella Ezcurra, Decker, Di Donato, Ding, Duffy, Eberle, Eckmann, Eggens, Eulalio, Faehnle, Fenger-Gron, Forstemann, Frazao, Garneau, Gatfield, Graham, Graham, Grima, Groen, Gudipati, Haas, Hales, Han, Han, Heo, Hopkins, Hou, Iwasaki, Jonas, Jones, Jones, Jones, Juvvuna, Kaberdin, Kadaba, Kahvejian, Katoh, Kim, Kim, Kinoshita, Kiss, Kowalinski, Larimer, Lebreton, Lee, Li, Lim, Lin, Liu, Londin, Lowell, Lubas, Makino, Malecki, Malet, Mamolen, Marin-Vicente, Maryati, Mata, Mitchell, Modepalli, Molleston, Moon, Morris, Mullen, Murakami, Murray, Nagarajan, Newbury, Ng, Nishioka, Ohkura, Okada, Orban, Pandey, Park, Pashler, Peng, Perez-Ortin, Pfeiffer, Pirouz, Preker, Presnyak, Rehwinkel, Reimao-Pinto, Reimao-Pinto, Reis, Reiter, Rissland, Rose, Russo, Schaeffer, Schaeffer, Schaeffer, Schertel, Schneider, Schneider, Schneider, Schoenberg, Sharif, Sinturel, Smith, Snee, Spasic, Staals, Steinbrunn, Suh, Synowsky, Temme, Temme, Tharun, Thomas, Till, Tomari, Tomecki, Tomecki, Towler, Towler, Towler, Ustianenko, Vallejo, Vindry, Wahle, Waldron, Wan, Wasmuth, Wei, Wells, Wolf, Wyers, Wyman, Yamashita, Zabolotskaya, Zhang   +164 more
core   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

The first small-molecule inhibitors of members of the ribonuclease E family [PDF]

, 2015
The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression.
A Danchin, A Koul, AJ Callaghan, AJ Callaghan, AJ Callaghan, AJ Carpousis, AJ Carpousis, AP Walsh, AR Subramanian, BK Ghora, BK Mohanty, BK Shoichet, C Condon, C Condon, C Dye, CM Arraiano, D Apirion, D Suck, GA Mackie, JE Clarke, K Lee, KH Bleicher, KJ McDowall, KJ McDowall, L Kime, L Kime, M Kuwano, M Ono, M Wachi, MC Ow, MHJ Seifert, MJ Marcaida, N Guex, O Guner, O Zelenko, SM Garrey, SS Jourdan, V Khemici, VJ Gillet, VR Kaberdin, XQ Jiang, Y Redko, Z Zsoldos, ZW Li   +43 more
core   +4 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair [PDF]

, 2013
Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
A Vaisman, AL Lu, Alexandra Vaisman, AR Fernández de Henestrosa, B Hiller, B Rydberg, B Van Houten, BD Davis, Bennett Van Houten, D Mu, DJ Crowley, DL Croteau, DL Croteau, DM Maron, Donald Huston, E Curti, E Wolff, EA Kouzminova, EF DeRose, EG Frank, EG Frank, EW Hou, F Lazzaro, G Churchward, G Jiang, GF Moolenaar, H Krokan, H Ohmori, H Shinagawa, H Wang, IJ Fijalkowska, J Yang, JA Brown, JB Sweasy, JC Huang, JE Sale, JG Moggs, JJ Lin, JJ Truglio, JL Sparks, John P. McDonald, JP McDonald, K Sugasawa, L Garibyan, L Zheng, LA Christensen, Lili Liu, M Sandigursky, M Skorvaga, M Tang, M Watanabe-Akanuma, M Yamaguchi, MA Reijns, MC Wahl, ME Branum, MM Ghodgaonkar, MR Albertella, N Kim, Q Jiang, Q Ruan, R Cone, R Woodgate, RJ Sanderson, Roger Woodgate, RP Cunningham, SA Lujan, SA Nick McElhinny, SA Nick McElhinny, Sue Jinks-Robertson, T Baba, T Lindahl, T Lindahl, T Nakano, W Kuban, W Yang, Wojciech Kuban, Y Shen, YW Kow   +77 more
core   +3 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Nature Communications, 2018
Resistance of gRNA to ubiquitous ribonucleases is required for CRISPR-Cas9-based therapeutics. Here, the authors explore chemical modifications at all positions of the crRNA guide and tracrRNA cofactor, and identify modified versions that are more potent
Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, Erik J. Sontheimer   +9 more
doaj   +1 more source

Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases

Molecules, 2018
Ribonucleases are proteins whose use is promising in anticancer therapy. We have previously constructed different human pancreatic ribonuclease variants that are selectively cytotoxic for tumor cells by introducing a nuclear localization signal into ...
David Roura Padrosa, Jessica Castro, Alejandro Romero-Casañas, Marc Ribó, Maria Vilanova, Antoni Benito   +5 more
doaj   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source