Results 101 to 110 of about 167,361 (378)

Box H/ACA Small Ribonucleoproteins [PDF]

Molecular Cell, 2010
Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as ribonucleoprotein (RNP) enzymes mainly in the site-specific pseudouridylation of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs).
Kiss, Tamás, Fayet-Lebaron, Eléonore, Jády, Beáta E.   +2 more
openaire   +2 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Progress in 7SK ribonucleoprotein structural biology

Frontiers in Molecular Biosciences, 2023
The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function ...
Momodou B. Camara, Amr M. Sobeh, Catherine D. Eichhorn, Catherine D. Eichhorn   +3 more
doaj   +1 more source

Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]

, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Elkak, AE, Mokbel, K, Newbold, RF, Thomas, V   +3 more
core   +3 more sources

Double-gene targeting with preassembled Cas9 ribonucleoprotein for safe genome editing in the edible mushroomPleurotus ostreatus [PDF]

, 2023
Tatpong Boontawon, Takehito Nakazawa, Yeon-Jae Choi, Hyeon‐Su Ro, Minji Oh, Moriyuki Kawauchi, Masahiro Sakamoto, Yoichi Honda   +7 more
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Do we need broad immunological work-up in all patients with CIS? [PDF]

, 2012
BACKGROUND: The aim of this study was to determine the prevalence of altered immunological tests and their clinical significance in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). ----- PATIENTS AND METHODS:
Adamec, Ivan, Bošković, Mateja, Gabelić, Tereza, Habek, Mario, Posavec, Vanja, Radmilović, Marin, Škvorc, Ana   +6 more
core   +1 more source

Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

bioRxiv, 2018
Ribonucleoprotein (RNP) granules are membraneless liquid condensates that dynamically form, dissolve, and mature into a gel-like state in response to changing cellular environment.
Taranpreet Kaur, Ibraheem Alshareedah, Wen Wang, Jason A. Ngo, M. M. Moosa, Priya R Banerjee   +5 more
semanticscholar   +1 more source

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

Advanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti, Petr Michálek, Zbyněk Heger, Martin Pumera   +3 more
wiley   +1 more source

High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes

Genetics, 2015
Homology-directed repair (HDR) of breaks induced by the RNA-programmed nuclease Cas9 has become a popular method for genome editing in several organisms. Most HDR protocols rely on plasmid-based expression of Cas9 and the gene-specific guide RNAs.
Alexandre Paix, Andrew W. Folkmann, D. Rasoloson, G. Seydoux   +3 more
semanticscholar   +1 more source