Results 131 to 140 of about 121,107 (346)

An intimate view of a spliceosome component

eLife, 2015
A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
doaj   +1 more source

Formation of Particulate Ribonucleoprotein with Enzymic Activities in vitro. [PDF]

, 1958
Agnar P. Nygaard, Veikko Nurmikko, K. Hartiala, K. Hartiala, S. Veige, E. Diczfalusy   +5 more
openalex   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Developmental transcriptomes predict adult social behaviours in the socially flexible sweat bee, Lasioglossum baleicum

Molecular Ecology, EarlyView., 2023
Abstract Natural variation can provide important insights into the genetic and environmental factors that shape social behaviour and its evolution. The sweat bee, Lasioglossum baleicum, is a socially flexible bee capable of producing both solitary and eusocial nests.
Kennedy S. Omufwoko, Adam L. Cronin, Thi Thu Ha Nguyen, Andrew E. Webb, Ian M. Traniello, Sarah D. Kocher   +5 more
wiley   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

PLoS ONE, 2013
BackgroundHeterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form
Rachel W Anantha, Allen L Alcivar, Jianglin Ma, Hong Cai, Srilatha Simhadri, Jernej Ule, Julian König, Bing Xia   +7 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR-15b-5p and miR-7-1-3p processing in nasopharyngeal carcinoma. [PDF]

Mol Oncol
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Fan C, Tan F, Wu J, Zeng Z, Guo W, Huang H, Xiong W.   +6 more
europepmc   +2 more sources

Abstract Conformer Space

Helvetica Chimica Acta, EarlyView.
Proteins are intrinsically flexible and thus require an ensemble description. In abstract conformer space, ensemble diversity is easier to assess and the required ensemble size can be established. Abstract Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other.
Gunnar Jeschke
wiley   +1 more source

Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity [PDF]

, 2019
Poly-arginine peptide-18 (R18) has recently emerged as a highly effective neuroprotective agent in experimental stroke models, and is particularly efficacious in protecting cortical neurons against glutamic acid excitotoxicity.
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

The centrosome and spindle as a ribonucleoprotein complex [PDF]

Chromosome Research, 2011
The notion of nucleic acids in the spindle, and particularly, the centrosome has a long history of inquiry, doubt, and debate. However, the association of specific RNAs with these structures is now confirmed by several investigators. What their presence means for the assembly, function, and evolution of the cell division apparatus is not known; but ...
openaire   +3 more sources