Results 151 to 160 of about 167,361 (378)
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
CRISPR ribonucleoprotein-mediated genetic engineering in plants
Plant Communications, 2021 Yingxiao Zhang, B. Iaffaldano, Yiping Qi
semanticscholar +1 more source
The multistructural forms of box C/D ribonucleoprotein particles
RNA: A publication of the RNA Society, 2018 Structural biology studies of archaeal and yeast box C/D ribonucleoprotein particles (RNPs) reveal a surprisingly wide range of forms. If form ever follows function, the different structures of box C/D small ribonucleoprotein particles (snoRNPs) may ...
Ge Yu, Yu Zhao, Hong Li
semanticscholar +1 more source
Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection. [PDF]
, 1987 Terence E. Martin +3 more
openalex +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
An intimate view of a spliceosome component
eLife, 2015 A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
doaj +1 more source
Genome Biology, 2017 Selection-free genome editing using Cas9 ribonucleoprotein embryo bombardment has been achieved for maize and wheat. This is a breakthrough that should make new breeding technologies more acceptable for worldwide use.
Felix Wolter, H. Puchta
semanticscholar +1 more source
Ribonucleoprotein Therapy in Alzheimer's Disease?
Aging, 2014 Age-related neurodegenerative pathologies like Alzheimer’s and Parkinson’s diseases are accelerated by a decline in neuronal homeostasis. In this issue of Cell Reports, Kang et al. [1] reports the post-transcriptional mechanisms that regulate the expression and processing of amyloid precursor protein (APP), a protein directly implicated in the ...
Je-Hyun, Yoon, Myriam, Gorospe
openaire +2 more sources
Advanced Science, EarlyView.By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source