Results 151 to 160 of about 144,340 (386)

An intimate view of a spliceosome component

eLife, 2015
A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
doaj   +1 more source

Deciphering human ribonucleoprotein regulatory networks

bioRxiv, 2018
RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs. Although in vivo binding sites of RBPs can now be determined genome-wide, most studies typically focused on individual RBPs.
N. Mukherjee, H. Wessels, S. Lebedeva, Marcin P. Sajek, Mahsa Ghanbari, Aitor Garzia, Alina Munteanu, Dilmurat Yusuf, T. Farazi, J. Hoell, K. Akat, A. Akalin, T. Tuschl, U. Ohler   +13 more
semanticscholar   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

CRISPR ribonucleoprotein-mediated genetic engineering in plants

Plant Communications, 2021
Yingxiao Zhang, B. Iaffaldano, Yiping Qi
semanticscholar   +1 more source

Electron microscopy studies of the coronavirus ribonucleoprotein complex

Protein & Cell, 2017
Coronaviruses are enveloped viruses that cause different diseases in humans and animals (Su et al., 2016). Murine hepatitis virus (MHV) causes hepatitis, enteritis and central nervous system diseases in rodents and is one of the beststudied coronaviruses.
M. Gui, Xin Liu, D. Guo, Zhen Zhang, Chang-cheng Yin, Yu Chen, Y. Xiang   +6 more
semanticscholar   +1 more source

The centrosome and spindle as a ribonucleoprotein complex [PDF]

Chromosome Research, 2011
The notion of nucleic acids in the spindle, and particularly, the centrosome has a long history of inquiry, doubt, and debate. However, the association of specific RNAs with these structures is now confirmed by several investigators. What their presence means for the assembly, function, and evolution of the cell division apparatus is not known; but ...
openaire   +3 more sources

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

PLoS ONE, 2013
BackgroundHeterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form
Rachel W Anantha, Allen L Alcivar, Jianglin Ma, Hong Cai, Srilatha Simhadri, Jernej Ule, Julian König, Bing Xia   +7 more
doaj   +1 more source

Regulation of polyribosome formation and protein synthesis in the uterus. Isolation of cytoplasmic ribonucleoprotein particles and the principal properties of the cell-free protein-synthesizing system [PDF]

, 1967
Ching-Sung Teng, Terrell H. Hamilton
openalex   +1 more source

Knocking out consumer concerns and regulator’s rules: efficient use of CRISPR/Cas ribonucleoprotein complexes for genome editing in cereals

Genome Biology, 2017
Selection-free genome editing using Cas9 ribonucleoprotein embryo bombardment has been achieved for maize and wheat. This is a breakthrough that should make new breeding technologies more acceptable for worldwide use.
Felix Wolter, H. Puchta
semanticscholar   +1 more source