Results 261 to 270 of about 121,107 (346)

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, Volume 37, Issue 23, June 12, 2025.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis. [PDF]

J Neurochem
Cheng F, Chapman T, Venturato J, Davidson JM, Polido SA, Rosa-Fernandes L, San Gil R, Suddull HJ, Zhang S, Macaslam CY, Szwaja P, Chung R, Walker AK, Rayner SL, Morsch M, Lee A.   +15 more
europepmc   +1 more source

Mago nashi controls auxin‐mediated embryo patterning in Arabidopsis by regulating transcript abundance

New Phytologist, Volume 247, Issue 1, Page 14-23, July 2025.
Liping Liu, Wen Gong, Regina Stöckl, Philipp Denninger, Uwe Schwartz, Mark A. Johnson, Thomas Dresselhaus   +6 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

The effect of the pandemic on autoantibody rates in the general population. [PDF]

Arch Rheumatol
Karabey M, Kaya H, Ceylan A, Kaba K, Özdemir M, Feyzioğlu B.   +5 more
europepmc   +1 more source

MRAS: Master Regulator Analysis of Alternative Splicing

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study developed a computational approach called MRAS, designed to identify master regulators of splicing differences across various biological contexts. In this framework, altered RBP expression, rather than spliceosomal mutations or other modifications, plays a central role in driving these splicing differences.
Lei Zhou, Yue Huang, Yang Zhao, Dan Guo, Xiao Wen, Ruihong Xu, Xuan Lv, Song Wu, Sicheng Jing, Zhaoqi Liu   +9 more
wiley   +1 more source

Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer. [PDF]

Int J Gen Med
Wang S, Zheng Q, Chen L.
europepmc   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source

Vanishing fingers: systemic sclerosis-associated acro-osteolysis. [PDF]

QJM
Yamamoto H, Taniguchi Y.
europepmc   +1 more source

The Mr 70,000 protein of the U1 small nuclear ribonucleoprotein particle binds to the 5' stem-loop of U1 RNA and interacts with Sm domain proteins.

, 1988
Jeffrey R. Patton, Thoru Pederson
openalex   +1 more source