Results 281 to 290 of about 144,340 (386)

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Proteomic Analysis of Transbronchial Biopsies to Discover Novel Biomarkers for Early Identification of Chronic Lung Allograft Dysfunction. [PDF]

Transplant Direct
Tahmasbpour E, Philp A, Sivasubramaniam V, Thomson C, Plit M, Ravipati A, Raftery M, Darley D.   +7 more
europepmc   +1 more source

PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. [PDF]

, 1989
S P Bjørn, A Soltyk, Jean D. Beggs, James D. Friesen   +3 more
openalex   +1 more source

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

Nature Structural &Molecular Biology, 2017
S. Fica, K. Nagai
semanticscholar   +1 more source

Past, present, and future strategies for detecting and quantifying circular RNA variants

The FEBS Journal, EarlyView.
Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley   +1 more source

Single-Cell Transcriptome Analysis Uncovers La Ribonucleoprotein 6 (LARP6) as a Dual Regulator of Proliferation and Immune Infiltration in Triple-Negative Breast Cancer. [PDF]

J Cell Mol Med
Yuan F, Liang G, Zhang Q, Luo B, Liu J, Wu X.   +5 more
europepmc   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

In vitro assembly of a pre-messenger ribonucleoprotein.

, 1983
I V Economidis, Thoru Pederson
openalex   +1 more source

Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen

The FEBS Journal, EarlyView.
We investigated the role of the signal regulatory protein alpha (SIRPα)/CD47 axis in phagocytosis by disrupting the SIRPA gene in the THP‐1 cell line. The SIRPα KO THP‐1 cells retained their monocyte and macrophage characteristics similar to their wild‐type (WT) counterparts.
Saitong Muneekaew, Pasut Sasithong, Koollawat Chupradit, Kritayaporn Saiprayong, Thunchanok Nuchphongsai, Methichit Wattanapanitch   +5 more
wiley   +1 more source

Attribution of psychiatric manifestations to systemic lupus erythematosus in Chinese patients: A retrospective study. [PDF]

World J Psychiatry
Geng WQ, Yang XX, Cao JY, Zhang SZ, Jiang YN, Wei J.   +5 more
europepmc   +1 more source