Results 71 to 80 of about 167,361 (378)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding

BMC Biology
Background Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants.
Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak   +5 more
doaj   +1 more source

Analysis of the extranucleolar ribonucleoprotein particles of Cycas revoluta Thunb. (Cycadaceae) and Ceratozamia mexicana Brongn. (Zamiaceae)

Botan‪ical Sciences, 2022
Background: Nuclear ribonucleoprotein particles play a key role in RNA processing and in the gene expression pathway. Interchromatin granules (GICs) involved in the metabolism of pre-messenger RNA (pre-mRNA) were described in Allium cepa and ...
Lourdes-Teresa Agredano-Moreno, María de Lourdes Segura-Valdez, Jaime Jiménez-Ramírez, Luis-Felipe Jiménez-García   +3 more
doaj   +1 more source

Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

Nature Communications, 2018
Cas9-mediated gene editing is a powerful tool for addressing research questions in arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by embryonic microinjection, which is challenging, is limited to a small number of
Duverney Chaverra-Rodriguez, V. Macias, G. Hughes, S. Pujhari, Yasutsugu Suzuki, David R. Peterson, Donghun Kim, Sage McKeand, J. Rasgon   +8 more
semanticscholar   +1 more source

Mirror‐Image 5S Ribonucleoprotein Complexes [PDF]

Angewandte Chemie, 2020
AbstractAfter realizing mirror‐image genetic replication, transcription, and reverse transcription, the biggest challenge in establishing a mirror‐image version of the central dogma is to build a mirror‐image ribosome‐based translation machine. Here, we chemically synthesized the natural and mirror‐image versions of three ribosomal proteins (L5, L18 ...
Jun‐Jie Ling, Chuyao Fan, Hong Qin, Min Wang, Ji Chen, Pernilla Wittung‐Stafshede, Ting F. Zhu   +6 more
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Characterization of LINE-1 ribonucleoprotein particles. [PDF]

PLoS Genetics, 2010
The average human genome contains a small cohort of active L1 retrotransposons that encode two proteins (ORF1p and ORF2p) required for their mobility (i.e., retrotransposition).
Aurélien J Doucet, Amy E Hulme, Elodie Sahinovic, Deanna A Kulpa, John B Moldovan, Huira C Kopera, Jyoti N Athanikar, Manel Hasnaoui, Alain Bucheton, John V Moran, Nicolas Gilbert   +10 more
doaj   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
A Ali, A Harris, A Moeller, A Smirnov Yu, BE Eddy, BJ Chen, C Loney, C Scholtissek, CJ Elleman, CM Chu, Colin Loney, D McGeoch, David Bhella, David Jackson, DN Mastronarde, E Fournier, Frazer J. Rixon, GL Ada, I Archetti, JR Gog, JR Kremer, JS Rossman, JS Rossman, KB Renegar, L Hoyle, L Liljeroos, LJ Calder, LM Burleigh, M Adrian, P Palese, PC Roberts, PC Roberts, Peter Palese, R Arranz, RA Lamb, RA Lamb, RW Compans, RW Ruigrok, Swetha Vijayakrishnan, T Noda, T Noda, TA Bharat, V Doceul, Worawit Suphamungmee, Y Fujii, Y Geng   +45 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin [PDF]

, 2018
Background: Due to the nature of viral RNA genomes, RNA viruses depend on many RNA-binding proteins (RBP) of viral and host origin for replication, dissemination and evasion of host RNA degradation pathways.
Garcia, Maria Laura, Marmisollé, Facundo Ernesto, Reyes Martinez, Carina Andrea   +2 more
core   +2 more sources