Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]
, 2008 RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W. +11 more
core +4 more sources
Molecules, 2011 There are more than 100 different ribonucleoside structures incorporated as post-transcriptional modifications, mainly in tRNA and rRNA of both prokaryotes and eukaryotes, and emerging evidence suggests that these modifications function as a system in ...
Peter C. Dedon +8 more
doaj +1 more source
ChemInform Abstract: SYNTHESIS OF TRICYCLIC RIBONUCLEOSIDES
Chemischer Informationsdienst, 1974 AbstractDas Kaliumsalz des Mercaptoinosins (I) wird mit Dibromalkanen (II) bzw. (V) in Gegenwart von Alkali zu den tricyclischen Verbindungen (III) bzw. (VI) umgesetz Im Falle des Dibrompentans (VII) wird nur ein Bis‐(thioinosyl)‐pentan (VIII) isoli Beim Erhitzen mit alkoholischer Salzsäure wird aus dem Ribonucleosid (III) der Ribofuranosylrest unter ...
Mikio Honjo +2 more
openaire +4 more sources
Structure of the Ribosomal RNA Decoding Site Containing a Selenium-Modified Responsive Fluorescent Ribonucleoside Probe. [PDF]
, 2017 Comprehensive understanding of the structure-function relationship of RNA both in real time and at atomic level will have a profound impact in advancing our understanding of RNA functions in biology.
Boerneke, Mark A +3 more
core +1 more source
Practical Silyl Protection of Ribonucleosides [PDF]
Organic Letters, 2013 AbstractA selective silylation of the 3′‐ or 2′‐hydroxyl groups is achieved by choosing the enantiomer of the catalyst.
Sunggi Lee +4 more
openaire +4 more sources
Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue [PDF]
, 2007 Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses.
Brown, Daniel M. +11 more
core +4 more sources
Application of ribonucleoside vanadyl complex (RVC) for developing a multifunctional tissue preservative solution. [PDF]
PLoS ONE, 2018 The quality of biological samples greatly affects the accuracy of scientific results. However, RNA in cryopreserved tissues gradually degrades during storage, leading to errors in the results of subsequent experiments.
Tzong-Ming Shieh +5 more
doaj +1 more source
Preparation of Modified RNA Sequences for Biological Research
CHIMIA, 2005 Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ...
Stefan Pitsch +11 more
doaj +1 more source
Molecules, 2022 An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves +3 more
doaj +1 more source
Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]
, 2015 We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert +2 more
core +3 more sources