Results 21 to 30 of about 22,086 (209)

Preparation of Modified RNA Sequences for Biological Research

CHIMIA, 2005
Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ...
Stefan Pitsch, Philipp Wenter, Alfred Stutz, Luc Reymond, Sébastien Porcher, Andreas Peer, Evelyne Muller, Muthulaniappan Meyyappan, Frédéric Meylan, Cyrille Denarie, Damian Ackermann, Xiaolin Wu   +11 more
doaj   +1 more source

Application of ribonucleoside vanadyl complex (RVC) for developing a multifunctional tissue preservative solution. [PDF]

PLoS ONE, 2018
The quality of biological samples greatly affects the accuracy of scientific results. However, RNA in cryopreserved tissues gradually degrades during storage, leading to errors in the results of subsequent experiments.
Tzong-Ming Shieh, Chi-Yuan Chen, Chuen Hsueh, Cheng-Chia Yu, Chin-Chuan Chen, Tong-Hong Wang   +5 more
doaj   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +2 more sources

Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

Molecules, 2022
An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero   +3 more
doaj   +1 more source

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts

BMC Cancer, 2020
Background All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML).
Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov, Dora Visnjic   +8 more
doaj   +1 more source

Processing of matched and mismatched rNMPs in DNA by archaeal ribonucleotide excision repair

iScience, 2023
Summary: Ribonucleoside monophosphates (rNMPs) are the main non-canonical nucleotides in genomic DNA, and their incorporation can occur as mismatches or matches in vivo.
Maurane Reveil, Lucie Chapel, Blandine Vourc’h, Audrey Bossé, Léa Vialle, Raphaël Brizard, Yann Moalic, Mohamed Jebbar, Ghislaine Henneke   +8 more
doaj   +1 more source

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues. [PDF]

PLoS Computational Biology, 2011
Cytosolic 5'-nucleotidase II (cN-II) regulates the intracellular nucleotide pools within the cell by catalyzing the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates.
Franck Gallier, Perrine Lallemand, Maïa Meurillon, Lars P Jordheim, Charles Dumontet, Christian Périgaud, Corinne Lionne, Suzanne Peyrottes, Laurent Chaloin   +8 more
doaj   +1 more source

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]

Current Protocols in Nucleic Acid Chemistry, 2017
AbstractOligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected ...
Geeta, Meher, Nabin K, Meher, Radhakrishnan P, Iyer   +2 more
openaire   +2 more sources

Molnupiravir Does Not Induce Mutagenesis in Host Lung Cells during SARS-CoV-2 Treatment

Bioinformatics and Biology Insights, 2022
As SARS-CoV-2 continues to evolve and spread with the emergence of new variants, interest in small molecules with broad-spectrum antiviral activity has grown.
John Maringa Githaka
doaj   +1 more source

DFT Based QSAR Study of Enzyme Ribonucleoside Diphosphate Reductase

E-Journal of Chemistry, 2010
Quantum chemical descriptors such as heat of formation, energy of HOMO, total energy, absolute hardness and chemical potential in different combinations have been used to develop QSAR models of inhibitors of enzyme ribonucleoside diphosphate reductase ...
Mohiuddin Ansari, Ahmad Khalid Raza Khan, Suhail Ahmad Khan   +2 more
doaj   +1 more source