Results 31 to 40 of about 22,086 (209)
Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
Viruses, 2015 The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard +5 more
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AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
Cells, 2021 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer ...
Dora Višnjić +4 more
doaj +1 more source
Molecules, 2020 Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation.
Baole Zhang +9 more
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Orphanet Journal of Rare Diseases, 2021 Background Hydroxyurea is one of the earliest drugs that showed promise in the management of haemoglobinopathies that include β-thalassaemia and sickle cell disease.
Nirmani Yasara +2 more
doaj +1 more source
DNA Polymerases Engineered by Directed Evolution to Incorporate Nonstandard Nucleotides
Frontiers in Microbiology, 2014 DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ribonucleoside triphosphates. However, polymerases that can accept
Roberto eLaos +2 more
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Deoxyribo‐ and Ribonucleoside H‐Phosphonates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2001 AbstractMost methods for preparing H‐phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products.
Stawinski, Jacek, Strömberg, Roger
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2016 A series of seventeen β-hydroxyphosphonate ribonucleoside analogues containing 4-substituted-1,2,3-triazoles was synthesized and fully characterized. Such compounds were designed as potential inhibitors of the cytosolic 5’-nucleotidase II (cN-II), an ...
Tai Nguyen Van +7 more
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Biomedicines, 2023 The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear.
Cassandra Herbert +4 more
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Permeability of Coxiella burnetii to ribonucleosides [PDF]
Microbiology, 2002 Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D, Miller, Herbert A, Thompson
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Advanced Science, EarlyView.This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang +3 more
wiley +1 more source