Results 51 to 60 of about 22,086 (209)

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Uncontrolled host immunological reactions directed against tissue-trapped eggs precipitate a potentially lethal, pathological cascade responsible for schistosomiasis.
Kathrin K. Geyer, Sabrina E. Munshi, Martin Vickers, Michael Squance, Toby J. Wilkinson, Daniel Berrar, Cristian Chaparro, Martin T. Swain, Karl F. Hoffmann   +8 more
doaj   +1 more source

Diversity, Function and Activity of DNA Viruses in the Qiangyong Proglacial Lake Sediment, the Tibetan Plateau

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This study identified DNA viruses from Qiangyong proglacial lake sediments on the Tibetan Plateau, revealing a highly diverse and previously uncharacterized viral community. These viruses influence microbial community structure and function by infecting key nutrient‐transforming taxa and encoding auxiliary metabolic genes that modulate host metabolism.
Yang Zhao, Meiling Feng, Hongfei Chi, Keshao Liu, Rong Wen, Weizhen Zhang, Pengfei Liu   +6 more
wiley   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver. [PDF]

PLoS ONE, 2015
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct ...
Shudong Liu, Fei Jing, Chunxiao Yu, Ling Gao, Yejun Qin, Jiajun Zhao   +5 more
doaj   +1 more source

Proximity‐Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge‐Transfer Interactions

ChemistryEurope, Volume 4, Issue 1, January 2026.
Charge‐transfer assisted ligation (CTAL) enables ultrafast CuAAC and SPAAC conjugation of a tetra‐DiAlkoxyNaphthalene (DAN4)‐azide and a noncomplementary tetraNaphthaleneDiImide (NDI4)‐alkyne oligonucleotide under dilute conditions, and the reaction can be carried out tracelessly by subsequently removing the tags.
Laura Nicollet, Kévan Pérez de Carvasal, Nessrine Graidia, François Morvan, Michael Smietana   +4 more
wiley   +1 more source

Protocol for detecting RBM33-binding sites in HEK293T cells using PAR-CLIP-seq

STAR Protocols
Summary: RNA-binding proteins (RBPs) regulate gene expression both co-transcriptionally and post-transcriptionally. Here, we provide a protocol for photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation followed by next-generation ...
Fang Yu, Shun Liu, Allen C. Zhu, Chuan He, Zhijian Qian   +4 more
doaj   +1 more source

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

Rice Bran Supplements the Nutritional Density of Ready‐to‐Use Therapeutic Foods: A Targeted Nutrient and Non‐Targeted Metabolomic Analysis

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Incorporating rice bran in ready‐to‐use therapeutic foods (RUTFs) was used for treatment of childhood malnutrition. RUTF nutrient analysis showed increased dietary fiber and vitamins E and B1. Non‐targeted metabolomics revealed significant changes in lipids, amino acids, carbohydrates, vitamins, and phytochemicals corresponding to rice bran.
Annika M. Weber, Emma S. Bovaird, Sahar B. Toulabi, Silvia Barbazza, Moretta Damayanti Fauzi, Fildzah K. Putri, Khaerul Fadly, Kharisma Tamimi, Diva M. Calvimontes, Rimbawan Rimbawan, Zuraidah Nasution, Puspo Edi Giriwono, Frank T. Wieringa, Elizabeth P. Ryan   +13 more
wiley   +1 more source

Yerba Mate (Ilex paraguariensis A. St.‐Hil.) Reduces Oxidative Stress and Bone Resorption in Apical Periodontitis

International Endodontic Journal, Volume 59, Issue 1, Page 91-104, January 2026.
ABSTRACT Aim Apical periodontitis (AP) is a highly prevalent chronic inflammatory disease that can exert systemic effects by releasing biochemical mediators that initiate and regulate the immune response. Yerba Mate (Ilex paraguariensis, YM), a popular plant broadly consumed in South America, is rich in biologically active compounds known for their ...
Carolina Sayuri Wajima, Carolina de Barros Morais Cardoso, Caroline Anselmi, Renan Dal‐Fabbro, Murilo Catelani Ferraz, Cristiane Cantiga da Silva, Paulo César Ciarlini, Edilson Ervolino, Marco Cícero Bottino, Luciano Tavares Angelo Cintra   +9 more
wiley   +1 more source

Construction of a nrdA::luxCDABE Fusion and Its Use in Escherichia coli as a DNA Damage Biosensor

Sensors, 2008
The promoter of nrdA gene which is related with DNA synthesis was used to construct a DNA damage sensitive biosensor. A recombinant bioluminescent E.
Man Bock Gu, Byoung Chan Kim, Joo- Myung Ahn, Ee Taek Hwang   +3 more
doaj