Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis. [PDF]
PLoS ONE, 2010 Ribonucleotide reductases (RNRs) are essential enzymes that carry out the de novo synthesis of deoxyribonucleotides by reducing ribonucleotides. There are three different classes of RNRs (I, II and III), all having different oxygen dependency and ...
Anaïs Panosa +2 more
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Ribonucleotide reductases: Essential Enzymes for bacterial life [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell.
Eduard eTorrents
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Genetic characterization and role in virulence of the ribonucleotide reductases of Streptococcus sanguinis. [PDF]
J Biol Chem, 2014 Streptococcus sanguinis is a cause of infective endocarditis and has been shown to require a manganese transporter called SsaB for virulence and O2 tolerance. Like certain other pathogens, S.
Rhodes DV +7 more
europepmc +4 more sources
Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication [PDF]
Pathogens, 2023 Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis.
Chee-Hing Yang +5 more
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A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates. [PDF]
PLoS ONE, 2022 Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the ...
Talya S Levitz +5 more
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Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases [PDF]
eLife, 2022 Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and
Sofia N Moraes +6 more
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A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases [PDF]
Nature Communications, 2022 Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks. Here, the authors present the cryo-EM structure and mechanism of action of NrdR, the RNR-specific repressor, that controls transcription of RNR ...
Inna Rozman Grinberg +8 more
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Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria [PDF]
Current Research in Structural BiologyClass I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav +3 more
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Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase [PDF]
, 2013 Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides (NDPs or NTPs where N = C, U, G, or A) to 2′-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible for controlling the relative ratios and absolute concentrations of ...
Ellen C. Minnihan +2 more
openalex +4 more sources
Model Substrate/Inactivation Reactions for MoaA and Ribonucleotide Reductases: Loss of Bromo, Chloro, or Tosylate Groups from C2 of 1,5-Dideoxyhomoribofuranoses upon Generation of an α-Oxy Radical at C3 [PDF]
Molecules, 2020 We report studies on radical-initiated fragmentations of model 1,5-dideoxyhomoribofuranose derivatives with bromo, chloro, and tosyloxy substituents on C2.
Stanislaw F. Wnuk +3 more
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