TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress [PDF]
, 2022 Hiroyuki Ueno +17 more
openalex +1 more source
The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
, 2013 Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson +23 more
core +1 more source
Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]
, 2017 Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio +1 more
core +1 more source
The Plant Cell Online, 2006 Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair.
Chunxin Wang, Zhongchi Liu
semanticscholar +1 more source
Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor [PDF]
, 2015 Ferredoxins are iron-sulfur proteins that play important roles in electron transport and redox homeostasis. Yeast Apd1p is a novel member of the family of thioredoxin-like ferredoxins.
Chan, LC +8 more
core +1 more source
CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]
, 2016 The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Cook, Gregory M +7 more
core +3 more sources
Structural determinants and distribution of phosphate specificity in ribonucleotide reductases. [PDF]
J Biol Chem, 2021 Schell E +5 more
europepmc +1 more source
Essential Roles of Ribonucleotide Reductases under DNA Damage and Replication Stresses in Cryptococcus neoformans. [PDF]
Microbiol Spectr, 2022 Jung KW, Kwon S, Jung JH, Bahn YS.
europepmc +1 more source
A ribonucleotide reductase inhibitor with deoxyribonucleoside‐reversible cytotoxicity [PDF]
, 2016 Mikael Crona +5 more
openalex +1 more source