Results 201 to 210 of about 181,495 (258)

Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy. [PDF]

Front Pharmacol
Gregory A, Awad AM, Eltanani S, Yumnamcha T, Hart J, Me R, Lin X, Shawky M, Ibrahim AS.   +8 more
europepmc   +1 more source

Nuclear Quantum Effects in Quantum Mechanical/Molecular Mechanical Free Energy Simulations of Ribonucleotide Reductase. [PDF]

J Am Chem Soc
Chow M, Reinhardt CR, Hammes-Schiffer S.
europepmc   +1 more source

Profile of Catherine Drennan. [PDF]

Proc Natl Acad Sci U S A
Viegas J.
europepmc   +1 more source

Ribonucleotide reductase and DNA damage

, 2006
Pelle Håkansson
openalex   +1 more source

Azelaic Acid in Dermatology: A Review of Its Mechanism of Action. [PDF]

Cureus
Mariano-Rodriguez C, Nava-Martinez P, Diaz-Molina VL.   +2 more
europepmc   +1 more source

On the chemical mechanism of assembly of the tyrosyl radical-dinulcear iron cluster cofactor of E. coli ribonucleotide reductase

, 1993
J. Martin Bollinger
openalex   +1 more source

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Ribonucleotide Reductases

Annual Review of Biochemistry, 2006
Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks by catalyzing the substitution of the 2′OH-group of a ribonucleotide with a hydrogen by a mechanism involving protein radicals. Three classes of RNRs employ different mechanisms for the generation of the protein radical. Recent structural studies of members from each
Pär, Nordlund, Peter, Reichard
openaire   +3 more sources

Ribonucleotide reductases and radical reactions

Cellular and Molecular Life Sciences (CMLS), 1998
Ribonucleotide reductases (RNRs) catalyse the reduction of ribonucleotides to deoxyribonucleotides. They play a pivotal role in the regulation of DNA synthesis and are targets for antiproliferative drugs. Ribonucleotide reductases are unique enzymes in that they all require a protein radical for activity.
M. Fontecave
openaire   +3 more sources

Thiyl Radicals in Ribonucleotide Reductases

Science, 1996
The ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannii catalyzes adenosylcobalamin (AdoCbl)-dependent nucleotide reduction, as well as exchange of the 5′ hydrogens of AdoCbl with solvent. A protein-based thiyl radical is proposed as an intermediate in both of these processes. In the presence
S, Licht, G J, Gerfen, J, Stubbe
openaire   +3 more sources

8-azidoadenosine and ribonucleotide reductase

Biochemical and Biophysical Research Communications, 1992
Inhibitors of ribonucleotide reductase are potential antiproliferative agents, since they deplete cells from DNA precursors. Substrate nucleoside analogues, carrying azido groups at the base moiety, are shown to have strong cytostatic properties, as measured by the inhibition of the incorporation of thymidine into DNA.
B, Roy, M, Lepoivre, J L, Decout, J, Lhomme, M, Fontecave   +4 more
openaire   +2 more sources