Results 81 to 90 of about 181,495 (258)

ZmTH1 Is Vital for Healthy Plant Growth and Promotes Cold/Drought Tolerance by Regulating Thiamin Diphosphate‐Dependent Metabolisms in Maize

Plant Biotechnology Journal, EarlyView.
ABSTRACT Vitamin B1 (VB1) plays a crucial role in sustaining plant health and enabling adaptive responses to environmental stress. The complex maize genome implies a sophisticated VB1 synthesis pathway, with the mechanisms by which VB1 benefits plants remaining elusive.
Tengfei Zhang, Jie Zang, Boming Yang, Qiuxia Wang, Jijun Yan, Peiyong Xin, Jinfang Chu, Huabang Chen, Zhaogui Zhang   +8 more
wiley   +1 more source

Allosteric Control of Three B12-dependent (Class II) Ribonucleotide Reductases

Journal of Biological Chemistry, 1999
Three separate classes of ribonucleotide reductases are known, each with a distinct protein structure. One common feature of all enzymes is that a single protein generates each of the four deoxyribonucleotides.
R. Eliasson, E. Pontis, A. Jordan, P. Reichard   +3 more
semanticscholar   +1 more source

Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.

PLoS Pathogens, 2010
Ribonucleotide reductases (RRs) are evolutionarily-conserved enzymes that catalyze the rate-limiting step during dNTP synthesis in mammals. RR consists of both large (R1) and small (R2) subunits, which are both required for catalysis by the R1(2)R2(2 ...
Don B Gammon, Branawan Gowrishankar, Sophie Duraffour, Graciela Andrei, Chris Upton, David H Evans   +5 more
doaj   +1 more source

RRM1 (ribonucleotide reductase M1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on RRM1 (ribonucleotide reductase M1), with data on DNA, on the protein encoded, and where the gene is implicated.
Freeman, SN, Bepler, G
openaire   +2 more sources

Cell-cycle-dependent transcriptional and translational DNA-damage response of 2 ribonucleotide reductase genes in S. cerevisiae [PDF]

, 2012
The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells suggest that RNR mRNA production ...
Altschuler SJ, An X, Bregman A, Cai L, Cerqueira NM, Cerqueira NM, Chabes A, Chabes A, Chabes A, Domkin V, Elledge SJ, Hoeijmakers JH, Jordheim LP, Lee YD, Nick McElhinny SA, Perlstein DL, Raj A, Raj A, Sabouri N, Tan RZ, Tomar RS, Trcek T, Yao R, Youk H, Zenklusen D, Zhao X, Zhao X, Zhao X   +27 more
core   +1 more source

Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment

Journal of Applied Toxicology, Volume 46, Issue 2, Page 639-651, February 2026.
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira, H. Zapparoli, C. S. Mussi, P. C. Maiorka, A. F. C. Andrade, S. L. Górniak, A. T. Gotardo   +6 more
wiley   +1 more source

Ribonucleotide Reduction in Mycobacterium tuberculosis : Function and Expression of Genes Encoding Class Ib and Class II Ribonucleotide Reductases

Infection and Immunity, 2003
Mycobacterium tuberculosis, the causative agent of tuberculosis, possesses a class Ib ribonucleotide reductase (RNR), encoded by the nrdE and nrdF2 genes, in addition to a putative class II RNR, encoded by nrdZ.
Stephanie S. Dawes, Digby F. Warner, Liana Tsenova, Juliano Timm, John D. McKinney, Gilla Kaplan, Harvey Rubin, Valerie Mizrahi   +7 more
openalex   +3 more sources

O2 Activation at an Enzymatic Diiron Site: Bridging Ligand Substitutions Alter Diferric‐(Hydro)peroxo States

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Substituting the bridging carboxylates in diFe sulerythrin shifts the bridging ligand coordination from 1,3‐carboxylate to 1,1‐carboxylate, yielding all three diferrous bridging motifs in one protein. This shortens the Fe–Fe distance and increases reactivity with O2.
Jae‐Hun Jeoung, Stefan Rünger, Kilian Weißer, Jakob Ruickoldt, Samriddhi Bhattacharya, Christian Limberg, Holger Dobbek   +6 more
wiley   +1 more source

Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]

, 2017
Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K, Danthi, Pranav, Hiller, Bradley E, Perez, Encarnacion, Jr, Snyder, Anthony J, Thete, Deepti, Upton, Jason W   +6 more
core   +2 more sources

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source