BMN673 sensitizes rhabdomyosarcoma tumors to irradiation in vivo [PDF]
, 2020 Bone and soft tissue sarcomas are mesenchymal tumors that occur rarely in adults, representing only 1% of total malignancies, but comprise up to 13% of malignant tumors in children.1 Rhabdomyosarcoma, a soft tissue sarcoma that commonly affects children,
Jacob, Connor
core
NAD+-glycohydrolase from Streptococcus pyogenes shows cyclic ADP-ribose forming activity [PDF]
, 1995 Tadahiro Karasawa
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Phasentrennung von Nukleinsäuren: Mechanismen, Eigenschaften und Anwendungen
Angewandte Chemie, EarlyView.Jüngste Entdeckungen zeigen, dass einzelsträngige langkettige Nukleinsäuren temperaturinduziert phasentrennen und dabei mikrometergroße Kondensate bilden. Dieser Minireview fasst das aktuelle mechanistische Verständnis dieses Phänomens zusammen, beschreibt Strategien zur gezielten Kontrolle der physikalischen und chemischen Eigenschaften der Kondensate
Weixiang Chen +2 more
wiley +1 more source
Scientific Reports, 2018 Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells.
Mareike Bütepage +15 more
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ADP-ribose-acceptor hydrolase 2 ( Arh2 ) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival [PDF]
, 2023 Jiro Kato +13 more
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Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications
Angewandte Chemie International Edition, EarlyView.Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen +2 more
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Activity of NMN+, nicotinamide ribose and analogs in alcohol oxidation promoted by horse‐liver alcohol dehydrogenase [PDF]
, 1986 Sames Sicsic +3 more
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Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara +5 more
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Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation [PDF]
, 2013 Wookee Min +13 more
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Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells
Biotechnology and Bioengineering, EarlyView.ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch +7 more
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