Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10
Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of ...
Sophie Sleiman, Francois Dragon
doaj +1 more source
A genomic approach to the study of Tribolium castaneum genetics, development & evolution [PDF]
During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development ...
Savard, Joël
core
Next generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploids [PDF]
© 2012 Matyášek et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Fulnecek, J+7 more
core +4 more sources
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang+6 more
wiley +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang+4 more
wiley +1 more source
RIBOSOMAL IMMUNOCORRECTION EFFICACY ASSESSMENT
Respiratory pathology and acute respiratory infections make the major part of all pediatric diseases. This pathology is a matter of special importance especially in the group of frequently-sick children.
O.V. Iozefovich+2 more
doaj +2 more sources
Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation
Ribosome biogenesis involves the hierarchical assembly of several proteins and RNA components. Here the authors describe a mechanism for ribosomal protein S3 incorporation into 40S ribosomal subunits that involves S3 dimerization and stepwise ...
Valentin Mitterer+9 more
doaj +1 more source
Transcriptomic analysis of Ascaris suum larvae during their hepatopulmonary migration [PDF]
Common roundworms are important intestinal nematodes of man (Ascaris lumbricoides) and pig (Ascaris suum). During the first stages of the infection, the larvae of these parasites undergo a hepatopulmonary migration.
Gasser, Robin+4 more
core +1 more source
Integration of computational and experimental approaches for deciphering the underlying mechanism of biomolecular condensates and potential biomaterials design (Created in Biorender. Raza, Z. (2025) https://BioRender.com/irgmeqi). Abstract Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be ...
Qiang Zhu+10 more
wiley +1 more source