Results 141 to 150 of about 846,528 (387)

Geometry‐Guided Osteogenesis in Bone‐on‐a‐Chip Systems Using Triply Periodic Minimal Surface Scaffolds

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a bone‐on‐a‐chip platform incorporating TPMS scaffolds to study geometry‐dependent osteogenesis under dynamic flow. By tuning pore shape and solidity, it precisely controls mechanical cues, revealing how topological features and shear stress affect osteogenic differentiation and matrix formation.
Donggyu Kim   +5 more
wiley   +1 more source

Conformational switches control early maturation of the eukaryotic small ribosomal subunit

open access: yeseLife, 2019
Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5’ external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome.
Mirjam Hunziker   +5 more
doaj   +1 more source

Reconstructing phylogeny from RNA secondary structure via simulated evolution

open access: yes, 2002
DNA sequences of genes encoding functional RNA molecules (e.g., ribosomal RNAs) are commonly used in phylogenetics (i.e. to infer evolutionary history).
Fischer, Will, Geard, Nicholas
core  

Introducing ribosomal tandem repeat barcoding for fungi

open access: yesbioRxiv, 2018
Sequence analysis of the various ribosomal genetic markers is the dominant molecular method for identification and description of fungi. However, there is little agreement on what ribosomal markers should be used, and research groups utilize different ...
C. Wurzbacher   +7 more
semanticscholar   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

open access: yesAdvanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao   +6 more
wiley   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

open access: yesAdvanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan   +13 more
wiley   +1 more source

In vivo labelling of functional ribosomes reveals spatial regulation during starvation in Podospora anserina

open access: yesBMC Genetics, 2000
Background To date, in eukaryotes, ribosomal protein expression is known to be regulated at the transcriptional and/or translational levels. But other forms of regulation may be possible.
Silar Philippe, Lalucque Hervé
doaj   +1 more source

Differential distribution of rna and protein in the ribosomal fractions of escherichia coli [PDF]

open access: yes
Differential distribution of RNA and protein in ribosomal fractions of Escherichia ...
Raacke, I. D.
core   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan   +20 more
wiley   +1 more source

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