Results 51 to 60 of about 846,528 (387)

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function [PDF]

, 2020
Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene to the connectivity $k$ of the corresponding protein in the PPI networks ...
Cimini, Giulio, Dilucca, Maddalena, Giansanti, Andrea   +2 more
core   +2 more sources

The Protist Ribosomal Reference database (PR2): a catalog of unicellular eukaryote Small Sub-Unit rRNA sequences with curated taxonomy

Nucleic Acids Res., 2012
The interrogation of genetic markers in environmental meta-barcoding studies is currently seriously hindered by the lack of taxonomically curated reference data sets for the targeted genes.
L. Guillou, Dipankar Bachar, S. Audic, D. Bass, Cédric Berney, L. Bittner, C. Boutte, G. Burgaud, C. Vargas, J. Decelle, J. Campo, J. Dolan, Micah Dunthorn, B. Edvardsen, M. Holzmann, W. Kooistra, E. Lara, Noan Le Bescot, R. Logares, F. Mahé, R. Massana, M. Montresor, R. Morard, F. Not, J. Pawłowski, I. Probert, Anne-Laure Sauvadet, R. Siano, T. Stoeck, D. Vaulot, P. Zimmermann, R. Christen   +31 more
semanticscholar   +1 more source

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

Tumor Biology, 2017
Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation ...
Meng Pu, Jianlin Wang, Qike Huang, Ge Zhao, Congcong Xia, Runze Shang, Zhuochao Zhang, Zhenyuan Bian, Xishegn Yang, Kaishan Tao   +9 more
doaj   +1 more source

Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer

Analytical Cellular Pathology, 2022
Background. Characterization of the features associated with circulating tumor cells (CTCs) is one of major interests for predicting clinical outcome of colorectal cancer (CRC) patients.
Ruijun Pan, Chaoran Yu, Yanfei Shao, Hiju Hong, Jing Sun, Zhou Zhang, Peiyong Li, Minhua Zheng   +7 more
doaj   +1 more source

A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]

, 2009
BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Bull, TJ, Hermon-Taylor, J, Hinds, J, Linedale, R   +3 more
core   +3 more sources

Kinetic Studies on the Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in Intact Cells of Neurospora crassa [PDF]

, 1977
The transport of cytoplasmically synthesized mitochondrial proteins was investigated in whole cells of Neurospora crassa, using dual labelling and immunological techniques.
Hallermayer, Gerhard, Neupert, Walter, Zimmermann, Richard   +2 more
core   +1 more source

Ribosomal Proteins in Ribosome Assembly

Biomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +3 more sources

Regulation of ribosomal protein genes: An ordered anarchy

Wiley Interdisciplinary Reviews - RNA, 2020
Ribosomal protein genes are among the most highly expressed genes in most cell types. Their products are generally essential for ribosome synthesis, which is the cornerstone for cell growth and proliferation.
Cyrielle Petibon, Mustafa Malik Ghulam, Mathieu Catala, S. Abou Elela   +3 more
semanticscholar   +1 more source

Association between semen microbiome disorder and sperm DNA damage

Microbiology Spectrum
DNA fragmentation index (DFI), a new biomarker to diagnose male infertility, is closely associated with poor reproductive outcomes. Previous research reported that seminal microbiome correlated with sperm DNA integrity, suggesting that the microbiome may
Junxian He, Menghui Ma, Zhenhan Xu, Jintao Guo, Haicheng Chen, Xing Yang, Peigen Chen, Guihua Liu   +7 more
doaj   +1 more source