Results 51 to 60 of about 506,932 (296)

Oral microbiome signatures of post-stroke cognitive impairment

Frontiers in Microbiology
IntroductionTo investigate the characteristics of oral microbiota in patients with post-stroke cognitive impairment (PSCI) and to evaluate its potential as a noninvasive candidate microbial signature associated with PSCI.MethodsThis cross-sectional study
Jianchao Xu, Yingying Chang, Yingying Chang, Jiang Ma, Hui Wang, Xiaoyan Li, Xiuming Chen, Shu Niu, Yukun An, Yubin Zhao, Yubin Zhao   +10 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Association between semen microbiome disorder and sperm DNA damage

Microbiology Spectrum
DNA fragmentation index (DFI), a new biomarker to diagnose male infertility, is closely associated with poor reproductive outcomes. Previous research reported that seminal microbiome correlated with sperm DNA integrity, suggesting that the microbiome may
Junxian He, Menghui Ma, Zhenhan Xu, Jintao Guo, Haicheng Chen, Xing Yang, Peigen Chen, Guihua Liu   +7 more
doaj   +1 more source

Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer

Analytical Cellular Pathology, 2022
Background. Characterization of the features associated with circulating tumor cells (CTCs) is one of major interests for predicting clinical outcome of colorectal cancer (CRC) patients.
Ruijun Pan, Chaoran Yu, Yanfei Shao, Hiju Hong, Jing Sun, Zhou Zhang, Peiyong Li, Minhua Zheng   +7 more
doaj   +1 more source

The ribosome prophecy [PDF]

Nature Reviews Molecular Cell Biology, 2015
A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications.
openaire   +2 more sources

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy [PDF]

, 2006
Ribosomal proteins are assumed to stabilize specific RNA structures and promote compact folding of the large rRNA. The conformational dynamics of the protein between the bound and unbound state play an important role in the binding process.
Wöhnert, Jens, Hendrik R. A. Jonker, Harald Schwalbe, Ilin, Serge, S. Kaspar Grimm, Grimm, Steffen Kaspar, Jens Wöhnert, Jonker, Hendrik R. A., Schwalbe, Harald (Prof. Dr.), Serge Ilin   +9 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Presence of bacterial DNA in synovial fluid from the temporomandibular joint in patients with temporomandibular joint disorders

Frontiers in Oral Health
IntroductionTemporomandibular joint disorders (TMJD) are common, affecting approximately 30% of the population. While the aetiology of TMJD has been considerably discussed, one aspect that has not been thoroughly investigated is the potential occurrence ...
Nikoo Bazsefidpay, Nikoo Bazsefidpay, Nikoo Bazsefidpay, Mattias Ulmner, Mattias Ulmner, Anastasios Damdimopoulos, Bodil Lund, Bodil Lund   +7 more
doaj   +1 more source

Nascent Ribosomes [PDF]

Cell, 2001
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source