Results 311 to 320 of about 534,315 (335)
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Ribosomal DNA and Neurological Disorders
Current Molecular MedicineRibosomal DNA (rDNA) is important in the nucleolus and nuclear organization of human cells. Defective rDNA repeat maintenance has been reported to be closely associated with neurological disorders, such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, depression, suicide, etc ...
Hong Zhou +6 more
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The Ribosomal DNA Plasmids of Entamoeba
Parasitology Today, 1998In most organisms, the nuclear ribosomal RNA (rRNA) genes are highly repetitive and arranged as tandem repeats on one or more chromosomes. In Entamoeba, however, these genes are located almost exclusively on extrachromosomal circular DNA molecules with no clear evidence so far of a chromosomal copy.
S, Bhattacharya, I, Som, A, Bhattacharya
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Nontranscribed spacers in Drosophila ribosomal DNA
Chromosoma, 1981Ribosomal DNA nontranscribed spacers in Drosophila virilis DNA have been examined in some detail by restriction site analysis of cloned segments of rDNA, nucleic acid hybridizations involving unfractionated rDNA, and base composition estimates. The overall G + C content of the spacer is 27--28%; this compares with 39% for rDNA as a whole, 40% for main ...
P M, Rae, T, Barnett, V L, Murtif
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Ribosomal DNA instability and genome adaptability
Chromosome Research, 2019Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. To meet the high cellular demand for ribosomes, all eukaryotes have numerous copies of ribosomal DNA (rDNA) genes that encode ribosomal RNA (rRNA), usually far in excess of the requirement for ribosome biogenesis.
Devika, Salim, Jennifer L, Gerton
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Chromatin states at ribosomal DNA loci
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Eukaryotic transcription of ribosomal RNAs (rRNAs) by RNA polymerase I can account for more than half of the total cellular transcripts depending on organism and growth condition. To support this level of expression, eukaryotic rRNA genes are present in multiple copies.
Stephan, Hamperl +5 more
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1988
The nucleolus organizer region (NOR) of maize chromosome 6 is now known to be the location of the 17/5.8/26S rDNA (hereafter termed 17/26S rDNA); this molecular information extends the NOR function to one of synthesizer as well as organizer. The extensive variation in ribosomal DNA (rDNA) multiplicity and the finding that much of the rDNA is in the NOR-
R. L. Phillips +3 more
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The nucleolus organizer region (NOR) of maize chromosome 6 is now known to be the location of the 17/5.8/26S rDNA (hereafter termed 17/26S rDNA); this molecular information extends the NOR function to one of synthesizer as well as organizer. The extensive variation in ribosomal DNA (rDNA) multiplicity and the finding that much of the rDNA is in the NOR-
R. L. Phillips +3 more
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Replicon size of yeast ribosomal DNA
Molecular and General Genetics MGG, 1984The ribosomal RNAs of the yeast Saccharomyces cerevisiae are transcribed from a 9K bp stretch of DNA which is reiterated about 120-fold in a continuous array, about 360 microns long, on chromosome XII. Although ARS activity has been detected in the repeat unit, the size and disposition of replicons along this array of identical genes has not hitherto ...
Walmsley, Richard M. +3 more
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Journal of Molecular Biology, 1980
Abstract We have analysed the ribosomal DNA of Calliphora erythrocephala, a Dipteran fly of the same sub-order as Drosophila melanogaster, through a series of rDNA † fragments cloned in a plasmid vector. We have mapped the sites for eight restriction enzymes within these plasmids, and positioned the regions coding for the 18 S and 28 S rRNAs within ...
K, Beckingham, R, White
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Abstract We have analysed the ribosomal DNA of Calliphora erythrocephala, a Dipteran fly of the same sub-order as Drosophila melanogaster, through a series of rDNA † fragments cloned in a plasmid vector. We have mapped the sites for eight restriction enzymes within these plasmids, and positioned the regions coding for the 18 S and 28 S rRNAs within ...
K, Beckingham, R, White
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Ribosome cycle emerges from DNA replication
Nature Reviews Molecular Cell Biology, 2017A modification of Meselson and Stahl's density gradient centrifugation method and a rare Texan yeast helped show that eukaryotic ribosomes dissociate and reform during translation.
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The evolution of eukaryotic ribosomal DNA
Biosystems, 1986Mutations occur randomly throughout the ribosomal DNA (rDNA) sequence. Molecular drive (unequal crossing-over, gene conversion, and transposition) spreads these variations through the multiple copies of rDNA. Forces of selection act upon the variants to favor and fix them or disfavor and eliminate them.
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