Results 91 to 100 of about 6,113,563 (357)

Pseudouridine Synthase RsuA Captures an Assembly Intermediate That Is Stabilized by Ribosomal Protein S17

Biomolecules, 2020
The ribosome is a large ribonucleoprotein complex that synthesizes protein in all living organisms. Ribosome biogenesis is a complex process that requires synchronization of various cellular events, including ribosomal RNA (rRNA) transcription, ribosome ...
Kumudie Jayalath, Sean Frisbie, Minhchau To, Sanjaya Abeysirigunawardena   +3 more
doaj   +1 more source

The isolation of differentially expressed cDNA clones from the filarial nematode Brugia pahangi [PDF]

, 1999
A cDNA library constructed from 3 day post-infective L3 of the filarial nematode Brugia pahangi was screened by differential hybridization with cDNA probes prepared from different life-cycle stages.
Devaney, E., Hunter, S.J., Martin, S.A., Tetley, L., Thompson, F.J.   +4 more
core   +1 more source

Escherichia coli Ribosomal Protein S1 Unfolds Structured mRNAs Onto the Ribosome for Active Translation Initiation

PLoS Biology, 2013
This study reveals novel insights into how Escherichia coli ribosomal protein S1 functions as an RNA chaperone on the ribosome, unfolding and positioning mRNAs for translation initiation.
Mélodie Duval, A. Korepanov, Olivier Fuchsbauer, P. Fechter, Andrea Haller, A. Fabbretti, L. Choulier, R. Micura, B. Klaholz, P. Romby, M. Springer, S. Marzi   +11 more
semanticscholar   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

RNA G-quadruplex structures control ribosomal protein production

Scientific Reports, 2021
Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA biology remain poorly defined.
Dhaval Varshney, Sergio Martinez Cuesta, Barbara Herdy, Ummi Binti Abdullah, David Tannahill, Shankar Balasubramanian   +5 more
doaj   +1 more source

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Ribosomal protein L32 enhances hepatocellular carcinoma progression

Cancer Medicine, 2023
Purpose The underlying mechanisms of hepatocellular carcinoma (HCC) have not been fully investigated, and effective biomarkers for HCC are still needed to be explored.
Guoxin Hou, Zhimin Lu, Jialu Jiang, Xinmei Yang   +3 more
doaj   +1 more source

Multiple prebiotic metals mediate translation. [PDF]

, 2018
Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a ...
Bowman, Jessica C, Bray, Marcus S, Glass, Jennifer B, Haynes, Jay William, Hud, Nicholas V, Lenz, Timothy K, Petrov, Anton S, Reddi, Amit R, Williams, Loren Dean   +8 more
core   +1 more source

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

PLoS Genetics, 2013
Most yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with different subunit composition or specifically-tailored functions.
Monique N. O’Leary, Monique N. O’Leary, Katherine H. Schreiber, Katherine H. Schreiber, Yong Zhang, Anne Cécile E Duc, Shuyun Rao, J. Hale, Emmeline C. Academia, Shreya R. Shah, J. Morton, C. Holstein, Daniel Martin, M. Kaeberlein, W. Ladiges, P. Fink, V. Mackay, D. Wiest, Brian K. Kennedy, Brian K. Kennedy   +19 more
semanticscholar   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source