Results 91 to 100 of about 556,680 (355)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Survey and multigene characterization of stolbur phytoplasmas on various plant species in Serbia

Phytopathologia Mediterranea, 2013
Stolbur phytoplasmas were detected in 116 out of more than 200 samples from nine plant species col- lected in 2009‒2010 in Serbia. Phytoplasmas were detected and identified by restriction fragment length polymor- phism (RFLP) analysis of polymerase chain
Jelena MITROVIĆ, Snežana PAVLOVIĆ, Bojan DUDUK   +2 more
doaj   +1 more source

Ribosomal protein L32 enhances hepatocellular carcinoma progression

Cancer Medicine, 2023
Purpose The underlying mechanisms of hepatocellular carcinoma (HCC) have not been fully investigated, and effective biomarkers for HCC are still needed to be explored.
Guoxin Hou, Zhimin Lu, Jialu Jiang, Xinmei Yang   +3 more
doaj   +1 more source

Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]

, 2013
The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun, Doudna, Jennifer A, Zhou, Kaihong   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metallopanstimulin as a marker for head and neck cancer [PDF]

, 2004
BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC).
A Agrawal, A Dietz, BC Stack Jr, CS Hollenbeak, DJ Santa Cruz, DR Ganger, DR Ganger, E Tartour, H Kasai, H Naora, H Quon, IG Wool, IG Wool, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JA Fernandez-Pol, JT Wadsworth, JT Wadsworth, M Schmidt, PA Rockledge, RR Million, TN Teknos, VJ Lowe, WJ Lee, Y Atsuta, YL Chan, YL Chan   +28 more
core   +4 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

eLife, 2014
Cell-based studies showed that several Mdm2-binding ribosomal proteins, upon overexpression, stabilize and activate p53. In contrast, here we show in a mouse knockout study that Mdm2-binding ribosomal protein S27-like (Rps27l), upon disruption, activates
Xiufang Xiong, Yongchao Zhao, Fei Tang, Dongping Wei, Daffyd Thomas, Xiang Wang, Yang Liu, Pan Zheng, Yi Sun   +8 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source