Results 141 to 150 of about 339,294 (253)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Stoichiometry-induced differential selection on codon optimization among ribosomal protein genes in bacterial species. [PDF]

Mol Biol Evol
Xia X.
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Reduced levels of mitochondrial ribosomal protein MRPL54 does not alter Apc related adenoma formation. [PDF]

PLoS One
Spaan CN, Daniels E, Smit WL, de Boer RJ, Silva J, Vermeulen JLM, Meisner S, Muncan V, Houtkooper RH, Heijmans J.   +9 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability. [PDF]

Nat Commun
Gutierrez C, Kwok M, Ruthen N, Waddicor P, Curran C, Ouspenskaia T, Fu D, Smalec B, Sedor S, Knisbacher BA, Biran A, Nagler A, Garbicz F, Sewastianik T, Penailillo J, Lucas F, Yin S, Liani A, Chen S, Lazarian G, Witten E, Dangle N, Brunsting EL, Zheng M, Lin ES, Lee MJ, Wells B, Pomerance L, Hernández-Sánchez M, Li S, Lin Z, Al'Khafaji A, Wang L, Thakurela S, Livak KJ, Neuberg D, Cymbalista F, Getz G, Regev A, Churchman S, Ten Hacken E, Carrasco R, Shao S, Wu CJ.   +43 more
europepmc   +1 more source

Ribosomal Protein Dynamics on the Human Ribosome [PDF]

Biophysical Journal, 2018
Christopher Lapointe, Joseph Puglisi
openaire   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere. [PDF]

ISME J
Meza-Padilla I, Avrani S, Müller KM, Nissimov JI.   +3 more
europepmc   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source