While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond +7 more
wiley +2 more sources
YsxC is a placeholder for ribosomal protein uL2 during 50S ribosomal subunit assembly. [PDF]
Seffouh A, Arpin D, Basu K, Ortega J.
europepmc +1 more source
Ribosomal Protein RPL29 Promotes Hepatocellular Carcinoma Progression Through Regulation the Expression of Exosome Component 4. [PDF]
Wang X, Zhu Z.
europepmc +1 more source
Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance. [PDF]
Dopler A +13 more
europepmc +1 more source
Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood +6 more
wiley +2 more sources
Spatial regulation of ribosomal protein gene expression revealed by spatial transcriptomic analysis in the water fern <i>Ceratopteris richardii</i>. [PDF]
Han J, Li GS.
europepmc +1 more source
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner +5 more
wiley +1 more source
Exploring mitochondrial ribosomal protein S12 as a novel target for non-small cell lung cancer. [PDF]
Chen Z, Jin Y, Wei S, Wei R, Ding X.
europepmc +1 more source
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi +6 more
wiley +1 more source
Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function. [PDF]
Surya A +12 more
europepmc +1 more source

