Results 221 to 230 of about 540,233 (304)

Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz   +3 more
wiley   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

open access: yesBMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang   +12 more
wiley   +1 more source

Phylogenomics and Biogeography of the Eastern Asian–Eastern North American Disjunct Genus Hylodesmum (Fabaceae)

open access: yesBiological Diversity, EarlyView.
Integrating data from plastid genomes, nrDNA, and 353 low‐copy nuclear genes, this study establishes a robust phylogenetic framework for Hylodesmum. This framework supports a taxonomic revision recognizing 18 species and reveals a complex pattern of bidirectional EA–ENA dispersal, with mammals as a plausible dispersal agent. ABSTRACT Phylogenomics with
Zhuqiu Song   +5 more
wiley   +1 more source

Targeting mitochondrial ribosomal protein expression by andrographolide and melatonin for colon cancer treatment. [PDF]

open access: yesCancer Lett
Midde A   +12 more
europepmc   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo

open access: yesChemistry – A European Journal, EarlyView.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova   +2 more
wiley   +1 more source

Ribosomal protein mutation suppresses gonadal leader cell migration defects in mig-17/ADAMTS mutants in Caenorhabditis elegans. [PDF]

open access: yesSci Rep
Kim HS   +14 more
europepmc   +1 more source

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