Results 251 to 260 of about 6,113,563 (357)

Novel Intragenic Duplication of GATAD2B in a Patient With GAND

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The nucleosome remodeling and deacetylation (NuRD) complex is a major chromatin regulator and plays a critical role in regulating gene transcription, genome integrity, and cell cycle progression. Heterozygous variants in GATAD2B, a core NuRD component, have been reported to cause GATAD2B‐Associated Neurodevelopmental Disorder (GAND), an ...
Mari Mori, Steven Estes, Swetha Ramadesikan, Betsy Schmalz, Shayne Plourde, Maria E. Hernandez Gonzalez, Anthony R. Miller, Bimal P. Chaudhari, Richard K. Wilson, Daniel C. Koboldt   +9 more
wiley   +1 more source

The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations

Angewandte Chemie, EarlyView.
Natural alcohol and sugar dehydrogenases that utilize the redox cofactor pyrroloquinoline quinone (PQQ) can be repurposed for enantioselective photoredox catalysis. Upon blue‐light irradiation, redox‐neutral radical cyclizations are catalyzed. This work adds a new class of enzymes to the toolbox of photobiocatalysis.
Srishti B. Bahukhandi, Andreas S. Klein, Ghulam Mustafa, Maria Weyh, Alexandra Walter, Erling Thyrhaug, Jürgen Hauer, Golo Storch, Cathleen Zeymer   +8 more
wiley   +2 more sources

Dynamic Dysregulation of Ribosomal Protein Genes in Mouse Brain Stress Models. [PDF]

Stresses
Sharma V, Shukla R.
europepmc   +1 more source

Identification of ribosomal protein S25 (RPS25)–MDM2–p53 regulatory feedback loop

Oncogene, 2013
Xu Zhang, Xu Zhang, Wei Wang, Hui Wang, Ming-Hai Wang, Wenrong Xu, Ruiwen Zhang   +6 more
semanticscholar   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility. [PDF]

PLoS Pathog
Greene J, Cotten KL, Snyder RA, Huiszoon RC, Chu S, Braza RED, Chapin AA, Stine JM, Bentley WE, Ghodssi R, Davis KM.   +10 more
europepmc   +1 more source

New chromosomal location for structural genes of ribosomal proteins. [PDF]

, 1975
Robert J. Watson, Jack Parker, Niels P. Fiil, Joel G. Flaks, James D. Friesen   +4 more
openalex   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases

Angewandte Chemie, EarlyView.
COM domains are known as docking domains between subunits of nonribosomal peptide synthetases (NRPSs). Here, the first structure of a fused, internal COM domain with its neighboring domains is reported. Structural, biochemical and crosslinking data show that COM domains play an unexpected role in properly positioning epimerization (E) and condensation (
Julia Diecker, Benedikt Hermanns, Jennifer Rüschenbaum, René Rasche, Wolfgang Dörner, Alexander Schröder, Daniel Kümmel, Henning D. Mootz   +7 more
wiley   +2 more sources

Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth. [PDF]

Cell Commun Signal
Campeanu IJ, Jiang Y, Afisllari H, Dzinic S, Polin L, Yang ZQ.   +5 more
europepmc   +1 more source