Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu +8 more
wiley +1 more source
Loss of Drosophila ribosomal protein S6 kinase II causes mitochondrial dysfunction and cell death.
Deng T +4 more
europepmc +1 more source
Generation of ribosomal protein S1 mutants for improving of expression of difficult to translate mRNAs. [PDF]
Niemelä LRK, Pásztor A, Frey AD.
europepmc +1 more source
Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7. [PDF]
Donald M. Engelman +2 more
openalex +1 more source
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang +10 more
wiley +1 more source
Dynamic Dysregulation of Ribosomal Protein Genes in Mouse Brain Stress Models. [PDF]
Sharma V, Shukla R.
europepmc +1 more source
Primary structure of protein S19 from the small ribosomal subunit of Escherichia coli [PDF]
Makoto Yaguchi
openalex +1 more source
A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang +9 more
wiley +1 more source
Oxydifficidin, a potent <i>Neisseria gonorrhoeae</i> antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity. [PDF]
Kan J +7 more
europepmc +1 more source

