Results 21 to 30 of about 339,294 (253)

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

open access: yesHaematologica, 2014
Diamond-Blackfan anemia is a congenital erythroid hypoplasia caused by functional haploinsufficiency of genes encoding ribosomal proteins. Mutations involving the ribosomal protein S19 gene are detected in 25% of patients.
Pekka Jaako   +7 more
doaj   +1 more source

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

open access: yesTumor Biology, 2017
Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation ...
Meng Pu   +9 more
doaj   +1 more source

Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]

open access: yesMolecules, 2016
Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi   +3 more
openaire   +3 more sources

Ribosomal Proteins in Ribosome Assembly

open access: yesBiomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +4 more sources

Ribosomal Proteins [PDF]

open access: yesEuropean Journal of Biochemistry, 1971
All 21 ribosomal proteins from 30 S subunits of Escherichia coliwere isolated in a pure state by the following methods: separation of subunits by zonal centrifugation in B X V rotors, extraction of proteins, CM‐cellulose chromatography with pyridine formate gradients, gel filtration on Sephadex G‐100 and, in some cases, preparative polyacrylamide block
I, Hindennach   +2 more
openaire   +4 more sources

The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation

open access: yesRNA Biology, 2022
The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear export of pre-40S particles to the cytoplasm.
Ingrid Rössler   +7 more
doaj   +1 more source

Ancestral Interactions of Ribosomal RNA and Ribosomal Proteins [PDF]

open access: yesBiophysical Journal, 2017
We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components.
Kathryn A, Lanier   +3 more
openaire   +2 more sources

Alterations in the ribosomal machinery in cancer and hematologic disorders

open access: yesJournal of Hematology & Oncology, 2012
Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also ...
Shenoy Niraj   +6 more
doaj   +1 more source

The Up-Regulation of Ribosomal Proteins Further Regulates Protein Expression Profile in Female Schistosoma japonicum after Pairing. [PDF]

open access: yesPLoS ONE, 2015
Pairing of Schistosoma males and females leads to and maintains female sexual maturation. However, the mechanism by which pairing facilitates sexual maturation of females is not clear.
Jun Sun, Chen Li, Suwen Wang
doaj   +1 more source

Counting the Minutes

open access: yeseLife, 2020
A newly discovered mechanism that causes the 'Minute' phenotype in fruit flies can explain how organisms are able to eliminate the mutant cells that arise occasionally during development.
Stephano Mello, Dirk Bohmann
doaj   +1 more source

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