Results 311 to 320 of about 6,082,749 (396)

Poly(ethylene glycol)‐based Peptidomimetics (Pegtides) of Antimicrobial Peptides

ChemBioChem, Accepted Article.
Cationic amphipathic poly(ethylene glycol) (PEG)‐based polymers were generated with synthetic efficiencies allowing their evaluation as Antimicrobial Peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalised with guanyl groups, but different side‐chain lengths, and hydrophobic units displaying long ...
Conor Shine, John R. F. B. Connolly, Robert D. Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P. Buijs, Hawraa Shahrour, Nathaniel I. Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald-Hughes, Marc Devocelle   +13 more
wiley   +1 more source

Transactivation of programmed ribosomal frameshifting by a viral protein

Proceedings of the National Academy of Sciences of the United States of America, 2014
Yanhua Li, E. E. Treffers, S. Napthine, A. Tas, Longchao Zhu, Zhi Sun, S. Bell, B. Mark, P. V. van Veelen, M. V. van Hemert, A. Firth, I. Brierley, E. Snijder, Ying Fang   +13 more
semanticscholar   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, EarlyView.
Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki, Jumpei Sasabe   +4 more
wiley   +1 more source

Metabolic disruption impairs ribosomal protein levels, resulting in enhanced aminoglycoside tolerance. [PDF]

Elife
Shiraliyev R, Orman MA.
europepmc   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, EarlyView.
Previous studies reveal an unexpected tendency for amyloid aggregation in specific regions of the C‐terminal domain (CTD) of nucleophosmin 1 (NPM1), a nucleolar chaperone involved in acute myeloid leukemia (AML). Herein, several peptide analogs of NPM1264‐277 (amyloid core) with conservative substitutions are designed and evaluated through biophysical ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source

Corrigendum: Ribosomal protein L40e fused with a ubiquitin moiety is essential for the vegetative growth, morphological homeostasis, cell cycle progression, and pathogenicity of Cryptococcus neoformans. [PDF]

Front Microbiol
Zhao J, Yang Y, Fan Y, Yi J, Zhang C, Gu Z, Pan W, Gu J, Liao W, Fang W.   +9 more
europepmc   +1 more source

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico, Cami M. P. Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T. N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique P. C. Mulder   +8 more
wiley   +1 more source

Low Expression of Mitochondrial Ribosomal Protein S5 is Associated With Poor Prognosis in Patients With Clear Cell Renal Cell Carcinoma. [PDF]

Appl Immunohistochem Mol Morphol
Yang X, Han B, Xie Q, Li Y, Li Q, Hu X, Zhao H, Xu X.   +7 more
europepmc   +1 more source

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes

ChemBioChem, EarlyView.
Group II Introns (G2Is) are large self‐splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2, an unexpectedly proficient ribozyme, self‐splices not only in vitro, but also in Escherichia coli cells.
Deni Szokoli, Noemi E. Nwosu, Lukas M. Glatt, Hannes Mutschler   +3 more
wiley   +1 more source

Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome. [PDF]

EBioMedicine
Tsang E, Han VX, Flutter C, Alshammery S, Keating BA, Williams T, Gloss BS, Graham ME, Aryamanesh N, Pang I, Wong M, Winlaw D, Cardamone M, Mohammad S, Gold W, Patel S, Dale RC.   +16 more
europepmc   +1 more source