Results 61 to 70 of about 6,159,973 (405)

Ribosome Proteins Represented by RPL27A Mark the Development and Metastasis of Triple-Negative Breast Cancer in Mouse and Human

Frontiers in Cell and Developmental Biology, 2021
Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options. The lack of targeted therapies and poor prognosis of patients with TNBC have made it urgent to discover novel critical diagnosis and therapeutic targets
Weipeng Zhao, Xichuan Li, Weiqi Nian, Jun Wang, Xiaorui Wang, Linlin Sun, Ye Zhu, Zhongsheng Tong   +7 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Molecular mechanisms of ribosomal protein gene coregulation

Genes & Development, 2015
The 137 ribosomal protein genes (RPG) of Saccharomyces provide a model for gene coregulation. Reja et al. examine the positional and functional organization of their regulators (Rap1, Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID,
Rohit Reja, Vinesh Vinayachandran, Sujana Ghosh, B. Pugh   +3 more
semanticscholar   +1 more source

Ribosomal Proteins in Ribosome Assembly

Biomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +3 more sources

Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
Most ribosomal proteins in Saccharomyces cerevisiae are encoded by two paralogs that additively produce the optimal protein level for cell growth. Nonetheless, deleting one paralog of most ribosomal protein gene pairs results in a variety of phenotypes ...
Ryan J. Palumbo, Gabriele Fuchs, Sheila Lutz, M. Joan Curcio   +3 more
doaj   +1 more source

Eaf1p Is Required for Recruitment of NuA4 in Targeting TFIID to the Promoters of the Ribosomal Protein Genes for Transcriptional Initiation In Vivo. [PDF]

, 2015
NuA4 (nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes involved in ribosome biogenesis.
Bhaumik, Sukesh R, Sen, Rwik, Uprety, Bhawana   +2 more
core   +1 more source

Ribosomes and ribosomal RNA as chaperones for folding of proteins

Folding and Design, 1997
Provocative recent reports indicate that the large subunits of either prokaryotic or eukaryotic ribosomes have the capacity to promote refolding of denatured enzymes.Salt-washed Escherichia coli ribosomes are shown to promote refolding of denatured rhodanese.
Gisela Kramer, Boyd Hardesty, Ashley Coffman, Wieslaw Kudlicki   +3 more
openaire   +3 more sources

Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells

Advanced Science, 2021
Colorectal cancer, one of the most commonly diagnosed cancers worldwide, is often accompanied by uncontrolled proliferation of tumor cells. Dyskerin pseudouridine synthase 1 (DKC1), screened using the genome‐wide RNAi strategy, is a previously ...
Guangyan Kan, Ziyang Wang, Chunjie Sheng, Gong Chen, Chen Yao, Yizhi Mao, Shuai Chen   +6 more
doaj   +1 more source

Phylogenomics of Prokaryotic Ribosomal Proteins

PLoS ONE, 2011
Archaeal and bacterial ribosomes contain more than 50 proteins, including 34 that are universally conserved in the three domains of cellular life (bacteria, archaea, and eukaryotes). Despite the high sequence conservation, annotation of ribosomal (r-) protein genes is often difficult because of their short lengths and biased sequence composition.
Natalya Yutin, Pere Puigbò, Yuri I. Wolf, Eugene V. Koonin   +3 more
openaire   +7 more sources

The other lives of ribosomal proteins [PDF]

Human Genomics, 2010
Despite the fact that ribosomal proteins are the constituents of an organelle that is present in every cell, they show a surprising level of regulation, and several of them have also been shown to have other extra-ribosomal functions, such in replication, transcription, splicing or even ageing.
Panagiotis A. Tsonis, Rital B. Bhavsar, Leah N. Makley   +2 more
openaire   +4 more sources