Results 61 to 70 of about 5,829,574 (377)

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation

open access: yesbioRxiv, 2020
The non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, is the first viral protein that is synthesized in SARS-CoV-2 infected human cells to suppress host innate immune functions1,2.
K. Schubert   +9 more
semanticscholar   +1 more source

The other lives of ribosomal proteins [PDF]

open access: yesHuman Genomics, 2010
Despite the fact that ribosomal proteins are the constituents of an organelle that is present in every cell, they show a surprising level of regulation, and several of them have also been shown to have other extra-ribosomal functions, such in replication, transcription, splicing or even ageing.
Panagiotis A. Tsonis   +2 more
openaire   +4 more sources

On the Ribosomal Density that Maximizes Protein Translation Rate [PDF]

open access: yes, 2016
During mRNA translation, several ribosomes attach to the same mRNA molecule simultaneously translating it into a protein. This pipelining increases the protein production rate. A natural and important question is what ribosomal density maximizes the protein production rate.
arxiv   +1 more source

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency

open access: yesGastroenterology, 2014
Little is known about the genetic factors that contribute to familial colorectal cancer type X (FCCX), characterized by hereditary nonpolyposis colorectal carcinoma with no mismatch repair defects.
T. Nieminen   +12 more
semanticscholar   +1 more source

Ribosomal Proteins in Ribosome Assembly

open access: yesBiomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +2 more sources

Protein synthesis by single ribosomes [PDF]

open access: yesRNA, 2003
The ribosome is universally responsible for synthesizing proteins by translating the genetic code transcribed in mRNA into an amino acid sequence. Ribosomes use cellular accessory proteins, soluble transfer RNAs, and metabolic energy to accomplish the initiation, elongation, and termination of peptide synthesis.
VANZI, FRANCESCO   +4 more
openaire   +3 more sources

Ribosomal protein L32 enhances hepatocellular carcinoma progression

open access: yesCancer Medicine, 2023
Purpose The underlying mechanisms of hepatocellular carcinoma (HCC) have not been fully investigated, and effective biomarkers for HCC are still needed to be explored.
Guoxin Hou   +3 more
doaj   +1 more source

The social life of ribosomal proteins [PDF]

open access: yesThe FEBS Journal, 2005
Ribosomal proteins hold a unique position in biology because their function is so closely tied to the large rRNAs of the ribosomes in all kingdoms of life. Following the determination of the complete crystal structures of both the large and small ribosomal subunits from bacteria, the functional role of the proteins has often been overlooked when ...
Brodersen, Ditlev Egeskov, Nissen, Poul
openaire   +3 more sources

Differential stoichiometry among core ribosomal proteins [PDF]

open access: yesCell Reports 13: 865 - 873, 2015, 2014
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition.
arxiv   +1 more source

Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly [PDF]

open access: yesScience, 2012
Symportin Synchrony Ribosomes, the macromolecular machines responsible for protein synthesis, function in the cytoplasm but are assembled in the nucleus. Ribosomal proteins must be imported into the nucleus, but how this is coordinated with assembly is unclear. Kressler et al.
Dagmar Pratte   +12 more
openaire   +3 more sources

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